catalog number :
MBS9207934
products full name :
LMTK3 Antibody (C-term)
products short name :
[LMTK3]
products name syn :
[Serine/threonine-protein kinase LMTK3; Lemur tyrosine kinase 3; LMTK3; KIAA1883; TYKLM3]
other names :
[Serine/threonine-protein kinase LMTK3; Serine/threonine-protein kinase LMTK3; serine/threonine-protein kinase LMTK3; lemur tyrosine kinase 3; Lemur tyrosine kinase 3]
products gene name :
[LMTK3]
other gene names :
[LMTK3; LMTK3; LMR3; TYKLM3; PPP1R101; KIAA1883; TYKLM3]
uniprot entry name :
LMTK3_HUMAN
specificity :
This LMTK3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1192-1226 amino acids from the C-terminal region of human LMTK3.
purity :
Purified Rabbit Polyclonal Antibody (Pab)
form :
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
concentration :
Vial Concentration: 0.5
storage stability :
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
tested application :
Western Blot (WB), ELISA (EIA)
image1 heading :
Western Blot (WB)
other info1 :
Antigen Source: Human
other info2 :
Function: Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed: 21602804 ). Involved in endocytic trafficking of N-methyl- D-aspartate receptors (NMDAR) in neurons (By similarity). Cellular Location: Membrane {ECO:0000250 UniProtKB:Q5XJV6}; Single-pass membrane protein {ECO:0000250 UniProtKB:Q5XJV6}. Cell projection, axon {ECO:0000250 UniProtKB:Q5XJV6}. Cell projection, dendrite {ECO:0000250 UniProtKB:Q5XJV6}. Golgi apparatus membrane {ECO:0000250 UniProtKB:Q5XJV6}. Note=Punctate pattern in cell projections.
products categories :
Signal Transduction
products references :
Nagase T.,et al.DNA Res. 8:179-187(2001). Grimwood J.,et al.Nature 428:529-535(2004).
uniprot summary :
Lmr3: a dual-specificity kinase of the Lmr family. Protein type: Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; EC 2.7.11.1; TK group; Lmr family. Chromosomal Location of Human Ortholog: 19q13.33. Cellular Component: integral to membrane. Molecular Function: protein serine/threonine kinase activity; ATP binding. Biological Process: protein amino acid phosphorylation