COL5A2 Antibody (N-term) | MyBioSource MBS9207820 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

COL5A2 Antibody (N-term)

catalog :

MBS9207820

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, flow cytometry, FACS, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of COL5A2 Antibody (N-term) in mouse lung tissue lysates (35ug/lane). COL5A2 (arrow) was detected using the purified Pab.

image 2 :

COL5A2 Antibody (N-term) flow cytometric analysis of NCI-H460 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

product information

catalog number :

MBS9207820

products type :

Antibody

products full name :

COL5A2 Antibody (N-term)

products short name :

[COL5A2]

products name syn :

[Collagen alpha-2(V) chain; COL5A2]

other names :

[collagen alpha-2(V) chain preproprotein; Collagen alpha-2(V) chain; collagen alpha-2(V) chain; collagen, type V, alpha 2]

products gene name :

[COL5A2]

other gene names :

[COL5A2; COL5A2; EDSC]

uniprot entry name :

CO5A2_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human, mouse

sequence positions :

[90-118]

sequence length :

1499

specificity :

This COL5A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-118 amino acids from the N-terminal region of human COL5A2.

purity :

Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

storage stability :

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS)

app notes :

WB~~1:1000. FC~~1:10~50

image1 heading :

Western Blot (WB)

image2 heading :

Flow Cytometry (FC/FACS)

other info1 :

Function: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is aminor connective tissue component of nearlyubiquitous distribution. Type V collagen bindsto DNA, heparan sulfate, thrombospondin,heparin, and insulin. Type V collagen is a keydeterminant in the assembly of tissue-specific matrices (By similarity). Cellular location: Secreted, extracellular space, extra cellular matrix{ECO:0000255 PROSITE-ProRule:PRU00793}

other info2 :

Calculated MW: 144910

products categories :

Signal Transduction

products description :

COL5A2 is an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This protein is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations.

products references :

Menon,R., Reprod. Biol. Endocrinol. 7 (1), 62 (2009). Videman,T., Arthritis Rheum. 60 (2), 470-481 (2009). Segev,F., Invest. Ophthalmol. Vis. Sci. 47 (2), 565-573 (2006)

ncbi gi num :

89363017

ncbi acc num :

NP_000384.2

ncbi gb acc num :

NM_000393.3

uniprot acc num :

P05997

ncbi pathways :

Base Excision Repair Pathway (1290); Base Excision Repair Pathway (1290); Base Excision Repair Pathway (1290); Base Excision Repair Pathway (1290); Base Excision Repair Pathway (1290); Base Excision Repair Pathway (1290); Base Excision Repair Pathway (1290); Base Excision Repair Pathway (1290); Base Excision Repair Pathway (1290); Base Excision Repair Pathway (1290)

ncbi summary :

This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. [provided by RefSeq, Jul 2008]

uniprot summary :

COL5A2: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue- specific matrices. Defects in COL5A2 are a cause of Ehlers-Danlos syndrome type 1 (EDS1); also known as Ehlers-Danlos syndrome gravis or severe classic type Ehlers-Danlos syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome. Defects in COL5A2 are a cause of Ehlers-Danlos syndrome type 2 (EDS2); also known as Ehlers-Danlos syndrome mitis or mild classic type Ehlers Danlos syndrome. Belongs to the fibrillar collagen family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 2q14-q32. Cellular Component: extracellular matrix; collagen type V; endoplasmic reticulum lumen; extracellular region. Molecular Function: metal ion binding; extracellular matrix structural constituent; SMAD binding. Biological Process: skin development; collagen catabolic process; axon guidance; extracellular matrix disassembly; extracellular matrix organization and biogenesis; ossification; collagen fibril organization; skeletal development; eye morphogenesis. Disease: Ehlers-danlos Syndrome, Type I

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage