CYSLTR1 Antibody (Center) | MyBioSource MBS9207739 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CYSLTR1 Antibody (Center)

catalog :

MBS9207739

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

image

image 1 :

CYSLTR1 Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the CYSLTR1 antibody detected the CYSLTR1 protein (arrow).

image 2 :

CYSLTR1 Antibody (Center) (MBS9207739)immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CYSLTR1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

product information

catalog number :

MBS9207739

products type :

Antibody

products full name :

CYSLTR1 Antibody (Center)

products short name :

[CYSLTR1]

products name syn :

[Cysteinyl leukotriene receptor 1; CysLTR1; Cysteinyl leukotriene D4 receptor; LTD4 receptor; G-protein coupled receptor HG55; HMTMF81; CYSLTR1; CYSLT1]

other names :

[cysteinyl leukotriene receptor 1; Cysteinyl leukotriene receptor 1; cysteinyl leukotriene receptor 1; cysteinyl leukotriene receptor 1; Cysteinyl leukotriene D4 receptor; LTD4 receptor; G-protein coupled receptor HG55; HMTMF81]

products gene name :

[CYSLTR1]

other gene names :

[CYSLTR1; CYSLTR1; CYSLT1; CYSLTR; CYSLT1R; HMTMF81; CYSLT1; CysLTR1; LTD4 receptor]

uniprot entry name :

CLTR1_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human

sequence positions :

[144-172]

sequence length :

337

specificity :

This CYSLTR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-172 amino acids from the Central region of human CYSLTR1.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

tested application :

WB, IHC-P , E.

app notes :

WB~~1:1000. IHC-P~~1:10~50

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Calculated MW: 38541

other info2 :

Function: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >>LTE4 = LTC4 >> LTB4. Cellular Location: Cell membrane; Multi-pass membrane protein. Tissue Location: Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart.

products categories :

Neuroscience; GPCR Antibodies

products description :

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are. important mediators of human bronchial asthma. Pharmacologic. studies have determined that cysteinyl leukotrienes activate at. least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G. protein-coupled receptors. Activation of this receptor by LTD4. results in contraction and proliferation of smooth muscle, oedema,. eosinophil migration and damage to the mucus layer in the lung.

products references :

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Boulay, M.E., et al. Prostaglandins Leukot. Essent. Fatty Acids 83(1):15-22(2010). Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010). Hasegawa, S., et al. Platelets 21(4):253-259(2010). Sokolowska, M., et al. BMC Immunol. 10, 63 (2009) :

ncbi gi num :

532164733

ncbi acc num :

NP_006630.1

ncbi gb acc num :

NM_001282186.1

uniprot acc num :

Q9Y271

ncbi summary :

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

uniprot summary :

CYSLTR1: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 LTE4 = LTC4 LTB4. Belongs to the G-protein coupled receptor 1 family. Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: Xq13.2-q21.1. Cellular Component: membrane; integral to plasma membrane; plasma membrane. Molecular Function: protein binding; leukotriene receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; positive regulation of angiogenesis; calcium ion transport; positive regulation of vasoconstriction; defense response; respiratory gaseous exchange; inflammatory response; chemotaxis

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage