catalog number :
MBS9207649
products full name :
ITGA11 Antibody (N-term)
products short name :
[ITGA11]
products name syn :
[Integrin alpha-11; ITGA11]
other names :
[integrin alpha-11; Integrin alpha-11; integrin alpha-11; integrin, alpha 11]
products gene name :
[ITGA11]
other gene names :
[ITGA11; ITGA11; HsT18964]
uniprot entry name :
ITA11_HUMAN
reactivity :
Human, hamster, mouse
sequence positions :
[236-264]
specificity :
This ITGA11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-264 amino acids from the N-terminal region of human ITGA11.
purity :
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
form :
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
concentration :
Vial Concentration: 0.5
storage stability :
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
tested application :
Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS)
image1 heading :
Western Blot (WB)
image2 heading :
Western Blot (WB)
image3 heading :
Flow Cytometry (FC/FACS)
other info1 :
Antigen Type: Synthetic Peptide
other info2 :
Antigen Source: HUMAN
products categories :
Cancer; Signal Transduction
products description :
This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.
products references :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Lu, N., et al. Matrix Biol. 29(3):166-176(2010) Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009) Young, R.P., et al. Postgrad Med J 85(1008):515-524(2009) Barczyk, M.M., et al. J. Dent. Res. 88(7):621-626(2009)
ncbi acc num :
NP_001004439.1
ncbi gb acc num :
NM_001004439.1
ncbi summary :
This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008]
uniprot summary :
ITGA11: Integrin alpha-11/beta-1 is a receptor for collagen. Belongs to the integrin alpha chain family. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion. Chromosomal Location of Human Ortholog: 15q23. Cellular Component: focal adhesion; membrane; plasma membrane; integrin complex. Molecular Function: collagen binding; metal ion binding. Biological Process: substrate-bound cell migration; integrin-mediated signaling pathway; osteoblast differentiation; extracellular matrix organization and biogenesis; muscle development; cell-matrix adhesion; cell adhesion mediated by integrin; cell adhesion