Elongin A Antibody (N-term) | MyBioSource MBS9207620 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Elongin A Antibody (N-term)

catalog :

MBS9207620

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of Elongin A (arrow) using rabbit polyclonal Elongin A Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Elongin A gene.

image 2 :

Elongin A Antibody western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the Elongin A antibody detected the Elongin A protein (arrow).

product information

catalog number :

MBS9207620

products type :

Antibody

products full name :

Elongin A Antibody (N-term)

products short name :

[Elongin A]

products name syn :

[Transcription elongation factor B polypeptide 3; Elongin 110 kDa subunit; Elongin-A; EloA; RNA polymerase II transcription factor SIII subunit A1; SIII p110; TCEB3]

other names :

[transcription elongation factor B polypeptide 3; Transcription elongation factor B polypeptide 3; transcription elongation factor B polypeptide 3; transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A); Elongin 110 kDa subunit; Elongin-A; EloA; RNA polymerase II transcription factor SIII subunit A1; SIII p110]

products gene name :

[TCEB3]

other gene names :

[TCEB3; TCEB3; EloA; SIII; TCEB3A; SIII p110; EloA]

uniprot entry name :

ELOA1_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human, mouse

sequence positions :

[97-127]

sequence length :

798

specificity :

This Elongin A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-127 amino acids from the N-terminal region of human Elongin A.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

concentration :

Vial Concentration: 0.31

storage stability :

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB~~1:1000

image1 heading :

Western Blot (WB)

image2 heading :

Western Blot (WB)

other info1 :

Antigen Type: Synthetic Peptide

other info2 :

Antigen Source: HUMAN. Precautions: Elongin A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

products description :

Elongin A is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.

products references :

Beausoleil, S.A., et al., Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135 (2004). Tamura, K., et al., Biochem. Biophys. Res. Commun. 309(1):189-195 (2003). Kile, B.T., et al., Trends Biochem. Sci. 27(5):235-241 (2002). Yamazaki, K., et al., J. Biol. Chem. 277(29):26444-26451 (2002). Kamura, T., et al., J. Biol. Chem. 276(32):29748-29753 (2001).

ncbi gi num :

208022641

ncbi acc num :

NP_003189.2

ncbi gb acc num :

NM_003198.2

uniprot acc num :

Q14241

ncbi mol weight :

89909

ncbi summary :

This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008]

uniprot summary :

TCEB3: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). Heterotrimer of an A (A1, A2 or A3), B and C subunit. The C subunit mediates the binding of the elongin BC complex to subunit A. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 1p36.1. Cellular Component: nucleoplasm; extracellular space; cytoplasm; integral to membrane; nucleus. Molecular Function: DNA binding. Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; viral reproduction; positive regulation of viral transcription; RNA elongation from RNA polymerase II promoter; gene expression

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage