catalog number :
MBS9207250
products full name :
CRUM2 Antibody (C-term)
products short name :
[CRUM2]
products name syn :
[Protein crumbs homolog 2; Crumbs-like protein 2; CRB2]
other names :
[protein crumbs homolog 2; Protein crumbs homolog 2; protein crumbs homolog 2; crumbs family member 2; Crumbs-like protein 2]
products gene name :
[CRB2]
other gene names :
[CRB2; CRB2; FSGS9; VMCKD]
uniprot entry name :
CRUM2_HUMAN
reactivity :
Human, mouse
sequence positions :
[1258-1285]
specificity :
This CRUM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1258-1285 amino acids from the C-terminal region of human CRUM2.
purity :
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
form :
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
concentration :
Vial Concentration: 0.5
storage stability :
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
tested application :
Immunohistochemistry (IHC), Western Blot (WB)
app notes :
WB: 1:1000; IHC-P: 1:50~100
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Antigen Type: Synthetic Peptide
other info2 :
Antigen Source: HUMAN
products categories :
Cell Biology
products description :
Function: May play a role in polarized cells morphogenesis. Cellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Tissue Location: Expressed in retina, fetal eye and brain. Also expressed in kidney, ARPE-19 and RPE/choroid cell lines, and at low levels in lung, placenta, and heart.
ncbi acc num :
NP_775960.4
ncbi gb acc num :
NM_173689.6
uniprot summary :
CRB2: May play a role in polarized cells morphogenesis. Belongs to the Crumbs protein family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 9q33.3. Cellular Component: protein complex; integral to membrane; plasma membrane; lipid raft. Molecular Function: enzyme binding; aspartic-type endopeptidase inhibitor activity; calcium ion binding. Biological Process: somitogenesis; mesoderm formation; notochord formation; maintenance of epithelial cell polarity; positive regulation of BMP signaling pathway. Disease: Ventriculomegaly With Cystic Kidney Disease; Focal Segmental Glomerulosclerosis 9