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company name :
MyBioSource
product type :
antibody
product name :
HRIHFB2025 Antibody (C-term)
catalog :
MBS9206551
quantity :
0.08 mL
price :
155 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, flow cytometry, FACS, enzyme immunoassay
more info or order :
product information
catalog number :
MBS9206551
products type :
Antibody
products full name :
HRIHFB2025 Antibody (C-term)
products short name :
HRIHFB2025
products name syn :
Protein chibby homolog 1; ARPP-binding protein; Cytosolic leucine-rich protein; PIGEA-14; PKD2 interactor; Golgi and endoplasmic reticulum-associated 1; CBY1; ARB1; C22orf2; CBY; PGEA1
other names :
protein chibby homolog 1 isoform b; Protein chibby homolog 1; protein chibby homolog 1; chibby homolog 1 (Drosophila); ARPP-binding protein; Cytosolic leucine-rich protein; PIGEA-14; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1
products gene name :
CBY1
other gene names :
CBY1; CBY1; CBY; arb1; PGEA1; C22orf2; PIGEA14; PIGEA-14; HS508I15A; ARB1; C22orf2; CBY; PGEA1
uniprot entry name :
CBY1_HUMAN
clonality :
Polyclonal
isotype :
Rabbit Ig
host :
Rabbit
reactivity :
Human
sequence positions :
98-126
sequence length :
169
specificity :
This HRIHFB2025 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-126 amino acids from the C-terminal region of human HRIHFB2025.
purity :
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
form :
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
concentration :
Vial Concentration: 0.5
storage stability :
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
tested application :
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
app notes :
WB~~1:1000. IHC-P~~1:50~100. FC~~1:10~50
other info1 :
Antigen Type: Synthetic Peptide
other info2 :
Antigen Source: HUMAN. Cellular Location: Nucleus speckle. Golgi apparatus, trans- Golgi network. Note=Nuclear, in a punctate manner. Also found in the trans-Golgi. Tissue Location: dely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors
products categories :
Signal Transduction
products description :
Inhibits the Wnt/Wingless pathway by binding to beta catenin and inhibiting beta catenin mediated transcriptional activation by competing with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin 2/PKD2 and possibly of other intracellular proteins.
products references :
Gauci S., et.al., Anal. Chem. 81:4493-4501(2009).
ncbi gi num :
389886564
ncbi acc num :
NP_001002880.2
ncbi gb acc num :
NM_001002880.1
uniprot acc num :
Q9Y3M2
ncbi mol weight :
14470
ncbi summary :
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
uniprot summary :
CBY1: Inhibits the Wnt/Wingless pathway by binding to beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. Belongs to the chibby family. Protein type: Transcription regulation. Chromosomal Location of Human Ortholog: 22q12. Cellular Component: nucleoplasm; nuclear speck; trans-Golgi network; nucleus; cytosol. Molecular Function: identical protein binding; protein binding; beta-catenin binding. Biological Process: fat cell differentiation; protein localization; negative regulation of Wnt receptor signaling pathway; negative regulation of transcription, DNA-dependent; cardiac muscle cell differentiation
size1 :
0.08 mL
price1 :
155 USD
size2 :
0.4 mL
price2 :
340
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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