TRIM11 Antibody (C-term) | MyBioSource MBS9206358 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

TRIM11 Antibody (C-term)

catalog :

MBS9206358

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

image

image 1 :

TRIM11 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the TRIM11 antibody detected the TRIM11 protein (arrow).

image 2 :

TRIM11 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TRIM11 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

product information

catalog number :

MBS9206358

products type :

Antibody

products full name :

TRIM11 Antibody (C-term)

products short name :

[TRIM11]

products name syn :

[E3 ubiquitin-protein ligase TRIM11; 632-; Protein BIA1; RING finger protein 92; Tripartite motif-containing protein 11; TRIM11; RNF92]

other names :

[E3 ubiquitin-protein ligase TRIM11; E3 ubiquitin-protein ligase TRIM11; E3 ubiquitin-protein ligase TRIM11; tripartite motif containing 11; Protein BIA1; RING finger protein 92; Tripartite motif-containing protein 11]

products gene name :

[TRIM11]

other gene names :

[TRIM11; TRIM11; BIA1; RNF92; RNF92]

uniprot entry name :

TRI11_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human (Predicted Reactivity: Bovine, Rat)

sequence positions :

[300-329]

sequence length :

468

specificity :

This TRIM11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-329 amino acids from the C-terminal region of human TRIM11.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

tested application :

WB, IHC-P, E

app notes :

WB~~1:1000. IHC-P~~1:10~50

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Calculated MW: 52774

other info2 :

Function: E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressingviral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle. Cellular Location: Cytoplasm. Nucleus. Tissue Location: Ubiquitous

products categories :

Cell Biology; Neuroscience

products description :

The protein encoded by this gene is a member of the. tripartite motif (TRIM) family. The TRIM motif includes three. zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,. and a coiled-coil region. This protein localizes to the nucleus and. the cytoplasm. Its function has not been identified. [provided by. RefSeq].

products references :

Aurino, S., et al. Acta Myol 27, 90-97 (2008) :. Hong, S.J., et al. Biochem. Biophys. Res. Commun. 368(3):650-655(2008). Uchil, P.D., et al. PLoS Pathog. 4 (2), E16 (2008) :. Ishikawa, H., et al. FEBS Lett. 580(20):4784-4792(2006). Cooper, S.T., et al. BMC Genet. 6, 43 (2005) :

ncbi gi num :

21630277

ncbi acc num :

NP_660215.1

ncbi gb acc num :

NM_145214.2

uniprot acc num :

Q96F44

ncbi mol weight :

52774

ncbi pathways :

, Pathway (81559); , Pathway (81559); , Pathway (81559); , Pathway (81559)

ncbi summary :

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008]

uniprot summary :

TRIM11: E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle. Belongs to the TRIM/RBCC family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 6.3.2.-; Ubiquitin conjugating system; EC 6.3.2.19; Ligase; Ubiquitin ligase. Chromosomal Location of Human Ortholog: 1q42.13. Cellular Component: cytoplasm; nucleus. Molecular Function: protein domain specific binding; protein binding; zinc ion binding; ubiquitin-protein ligase activity; transcription factor binding; ligase activity. Biological Process: negative regulation of viral transcription; positive regulation of virion penetration into host cell; negative regulation of virion penetration into host cell; innate immune response; protein ubiquitination; negative regulation of transcription, DNA-dependent; defense response to virus; negative regulation of neurogenesis

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage