CCR7 Antibody (N-term) | MyBioSource MBS9205978 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CCR7 Antibody (N-term)

catalog :

MBS9205978

quantity :

0.08 mL

price :

150 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

image

image 1 :

All lanes : Anti-CCR7 Antibody (N-term) at 1:500-1:1000 dilution Lane 1: MDA-MB-231whole cell lysate Lane 2: MOLT-4 whole celllysate Lysates/proteins at 20 µg per lane.Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution.Predicted band size : 43 kDa Blocking/Dilutionbuffer: 5% NFDM/TBST.

image 2 :

Anti-CCR7 Antibody (Nterm) at 1:500 dilution+ MOLT-4 whole cell lysate Lysates/proteins at20 µg per lane. Secondary Goat Anti-RabbitIgG, (H+L), Peroxidase conjugated at 1/10000dilution. Predicted band size : 43 kDaBlocking/Dilution buffer: 5% NFDM/TBST.

product information

catalog number :

MBS9205978

products type :

Antibody

products full name :

CCR7 Antibody (N-term)

products short name :

[CCR7]

products name syn :

[C-C chemokine receptor type 7; C-C CKR-7; CC-CKR-7; CCR-7; BLR2; CDw197; Epstein-Barr virus-induced G-protein coupled receptor 1; EBI1; EBV-induced G-protein coupled receptor 1; MIP-3 beta receptor; CD197; CCR7; CMKBR7; EBI1; EVI1]

other names :

[C-C chemokine receptor type 7; C-C chemokine receptor type 7; C-C chemokine receptor type 7; chemokine (C-C motif) receptor 7; BLR2; CDw197; Epstein-Barr virus-induced G-protein coupled receptor 1; EBI1; EBV-induced G-protein coupled receptor 1; MIP-3 beta receptor; CD_antigen: CD197]

products gene name :

[CCR7]

other gene names :

[CCR7; CCR7; BLR2; EBI1; CCR-7; CD197; CDw197; CMKBR7; CC-CKR-7; CMKBR7; EBI1; EVI1; C-C CKR-7; CC-CKR-7; CCR-7; EBI1; EBV-induced G-protein coupled receptor 1]

uniprot entry name :

CCR7_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human, mouse

sequence positions :

[11-37]

sequence length :

378

specificity :

This CCR7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-37 amino acids from the N-terminal region of human CCR7.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

tested application :

WB, IHC-P, IF , FC, E

app notes :

WB~~1:1000. IHC-P~~1:10~50. IF~~1:10~50. FC~~1:10~50

image1 heading :

Western Blot WB

image3 heading :

Western Blot WB

image5 heading :

Western Blot WB

image5 description :

CCR7 Antibody (N-term) (MBS9205978)western blot analysis in 293(lane1),Ramos(lane 2),MDA-MB231(lane 3) cell lineand mouse spleen tissue(lane 4) lysates(35ug/lane).This demonstrates the CCR7antibody detected the CCR7 protein (arrow).

products categories :

Immunology; Signal Transduction; Phospho Antibodies

products description :

CCR7 is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor.

products references :

Sun, J., et al. Cell. Mol. Immunol. 7(1):77-82(2010) Wu, W.L., et al. Eur. J. Immunol. 39(12):3413-3422(2009) Marcenaro, E., et al. Blood 114(19):4108-4116(2009)

ncbi gi num :

4502641

ncbi acc num :

NP_001829.1

ncbi gb acc num :

NM_001838.3

uniprot acc num :

P32248

ncbi pathways :

, Pathway (1236); , Pathway (1236); , Pathway (1236); , Pathway (1236); , Pathway (1236); , Pathway (1236); , Pathway (1236); , Pathway (1236); , Pathway (1236); , Pathway (1236)

ncbi summary :

The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

uniprot summary :

CCR7: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Motility/polarity/chemotaxis; Receptor, GPCR. Chromosomal Location of Human Ortholog: 17q12-q21.2. Cellular Component: cell surface; plasma membrane; integral to membrane; intracellular; external side of plasma membrane. Molecular Function: G-protein coupled receptor activity; C-C chemokine receptor activity. Biological Process: positive regulation of cell adhesion; positive regulation of interleukin-12 production; positive regulation of dendritic cell antigen processing and presentation; positive regulation of JNK cascade; response to lipopolysaccharide; elevation of cytosolic calcium ion concentration; positive regulation of T cell receptor signaling pathway; positive regulation of humoral immune response; dendritic cell chemotaxis; establishment of T cell polarity; inflammatory response; positive regulation of cell-matrix adhesion; positive regulation of filopodium formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of hypersensitivity; positive regulation of phosphoinositide 3-kinase activity; negative thymic T cell selection; positive regulation of protein kinase B signaling cascade; G-protein coupled receptor protein signaling pathway; myeloid dendritic cell chemotaxis; positive regulation of pseudopodium formation; positive regulation of actin filament polymerization; regulation of interferon-gamma production; release of sequestered calcium ion into cytosol; positive regulation of protein kinase activity; ruffle organization and biogenesis; regulation of interleukin-1 beta secretion; immune response

size1 :

0.08 mL

price1 :

150 USD

more info or order :

MyBioSource product webpage