catalog number :
MBS9205809
products full name :
ENAM Antibody (C-term)
products short name :
[ENAM]
products name syn :
[Enamelin; ENAM]
other names :
[enamelin; Enamelin; enamelin; enamelin]
products gene name :
[ENAM]
other gene names :
[ENAM; ENAM; ADAI; AI1C; AIH2]
uniprot entry name :
ENAM_HUMAN
sequence positions :
[1097-1126]
specificity :
This ENAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1097-1126 amino acids from the C-terminal region of human ENAM.
purity :
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
form :
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
storage stability :
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
tested application :
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC-P), Flow Cytometry (FC/FACS)
app notes :
WB~~1:1000. IHC-P~~1:50~100. FC~~1:10~50
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
image3 heading :
Flow Cytometry (FC/FACS)
other info1 :
Function: Involved in the mineralization and structural organization of enamel. Involved un the extension of enamel during the secretory stage of dental enamel formation. Cellular Location: Secreted, extracellular space, extracellular matrix {ECO:0000250 UnitProtKB:O97939}. Tissue Location: Expressed in tooth particularly in odontoblast, ameloblast and cementoblast.
ncbi acc num :
NP_114095.2
ncbi gb acc num :
NM_031889.2
ncbi summary :
Dental enamel forms the outer cap of teeth and is the hardest substance found in vertebrates. This gene encodes the largest protein in the enamel matrix of developing teeth. The protein is involved in the mineralization and structural organization of enamel. Defects in this gene result in amelogenesis imperfect type 1C.[provided by RefSeq, Oct 2009]
uniprot summary :
enamelin: Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. Defects in ENAM are the cause of amelogenesis imperfecta type 1B (AI1B). AI1B is an autosomal dominant defect of enamel formation. Clinical manifestations may be variable. Some cases present with generalized enamel hypoplasia resulting in small, smooth, yellow and spaced teeth (smooth hypoplastic AI). Others show horizontal rows of pits, grooves or a hypoplastic area in the enamel (local hypoplastic AI). Defects in ENAM are the cause of amelogenesis imperfecta type 1C (AI1C); also known as amelogenesis imperfecta hypoplastic with or without openbite malocclusion. AI1C is an autosomal recessive defect of dental enamel formation. Teeth show hypoplastic and unmineralized enamel, and a yellow-brown discoloration. Enamel defects can be associated with facial and oral features including vertical dysgnathia and anterior openbite malocclusion. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 4q13.3. Cellular Component: proteinaceous extracellular matrix. Biological Process: biomineral formation. Disease: Amelogenesis Imperfecta, Type Ic; Amelogenesis Imperfecta, Type Ib