LTBP1 Antibody (C-term) | MyBioSource MBS9205431 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

LTBP1 Antibody (C-term)

catalog :

MBS9205431

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

image

image 1 :

LTBP1 Antibody (C-term) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the LTBP1 antibody detected the LTBP1 protein (arrow).

image 2 :

Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with LTBP1 antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

product information

catalog number :

MBS9205431

products type :

Antibody

products full name :

LTBP1 Antibody (C-term)

products short name :

[LTBP1]

products name syn :

[Latent-transforming growth factor beta-binding protein 1; LTBP-1; Transforming growth factor beta-1-binding protein 1; TGF-beta1-BP-1; LTBP1]

other names :

[latent-transforming growth factor beta-binding protein 1 isoform LTBP-1S; Latent-transforming growth factor beta-binding protein 1; latent-transforming growth factor beta-binding protein 1; latent transforming growth factor beta binding protein 1; Transforming growth factor beta-1-binding protein 1; TGF-beta1-BP-1]

products gene name :

[LTBP1]

other gene names :

[LTBP1; LTBP1; LTBP-1; TGF-beta1-BP-1]

uniprot entry name :

LTBP1_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human, mouse

sequence positions :

[1493-1525]

sequence length :

1395

specificity :

This LTBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1493-1525 amino acids from the C-terminal region of human LTBP1.

purity :

Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

storage stability :

Maintain refrigerated at 2-8°C for up to weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

tested application :

WB, IHC-P, E

app notes :

WB~~1:1000. IHC-P~~1:10~50

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Function: May be involved in the assembly, secretionand targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM). Cellular location: Cellular Location: Secreted. Tissue Location: Expressed in the aorta (at protein level). Isoform Long is found in fibroblasts

products categories :

Signal Transduction

products description :

LTBP1 may be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. This protein may play critical roles in controlling and directing the activity of TGFB1, and it may have a structural role in the extra cellular matrix (ECM).

products references :

Olofsson A., J. Biol. Chem. 270:31294-31297(1995). Kanzaki T., Cell 61:1051-1061(1990). Isogai Z., J. Biol. Chem. 278:2750-2757(2003). Oklu R., Biochem. J. 352:601-610(2000)

ncbi gi num :

261337167

ncbi acc num :

NP_000618.3

ncbi gb acc num :

NM_000627.3

uniprot acc num :

Q14766

ncbi pathways :

Pyruvate Metabolism Pathway (4052); Pyruvate Metabolism Pathway (4052); Pyruvate Metabolism Pathway (4052); Pyruvate Metabolism Pathway (4052); Pyruvate Metabolism Pathway (4052); Pyruvate Metabolism Pathway (4052); Pyruvate Metabolism Pathway (4052)

ncbi summary :

The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

uniprot summary :

LTBP1: May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM). Belongs to the LTBP family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Chaperone; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 2p22-p21. Cellular Component: extracellular matrix; proteinaceous extracellular matrix; protein complex; extracellular region; microfibril. Molecular Function: transforming growth factor beta receptor activity; protein binding; transforming growth factor beta binding; microfibril binding; calcium ion binding. Biological Process: extracellular matrix organization and biogenesis; transmembrane receptor protein serine/threonine kinase signaling pathway

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage