JAK1 Antibody (C-term) | MyBioSource MBS9205357 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

JAK1 Antibody (C-term)

catalog :

MBS9205357

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of lysates from HT-29 cell line and mouse spleen tissue lysate(from left to right), using JAK1 Antibody (C-term). MBS9205357 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.

product information

catalog number :

MBS9205357

products type :

Antibody

products full name :

JAK1 Antibody (C-term)

products short name :

[JAK1]

products name syn :

[Tyrosine-protein kinase JAK1; Janus kinase 1; JAK-1; JAK1; JAK1A; JAK1B]

other names :

[tyrosine-protein kinase JAK1; Tyrosine-protein kinase JAK1; tyrosine-protein kinase JAK1; Janus kinase 1; Janus kinase 1; JAK-1]

products gene name :

[JAK1]

other gene names :

[JAK1; JAK1; JTK3; JAK1A; JAK1B; JAK1A; JAK1B; JAK-1]

uniprot entry name :

JAK1_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human, mouse

sequence length :

1154

specificity :

This JAK1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 866-899 amino acids from the C-terminal region of human JAK1.

purity :

Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB~~1:1000

image1 heading :

Western Blot (WB)

other info1 :

Function: Tyrosine kinase of the non-receptor type,involved in the IFN-alpha/beta/gamma signalpathway (PubMed: href="http://www.uniprot.org/citations/7615558"target="_blank">7615558 ). Kinase partner for the interleukin (IL)-2 receptor(PubMed: 11909529). Cellular Location: Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated. Tissue Location: Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.

products categories :

Cancer; Cell Biology; Signal Transduction

products description :

Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.

products references :

Wilks A.F.,et al.Mol. Cell. Biol. 11:2057-2065(1991). Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases. Gregory S.G.,et al.Nature 441:315-321(2006). Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. Lee S.-T.,et al.Oncogene 8:3403-3410(1993).

ncbi gi num :

102469034

ncbi acc num :

NP_002218.2

ncbi gb acc num :

NM_002227.2

uniprot acc num :

P23458

ncbi mol weight :

133277

ncbi pathways :

, Pathway (3716); , Pathway (3716); , Pathway (3716); , Pathway (3716); , Pathway (3716); , Pathway (3716); , Pathway (3716); , Pathway (3716); , Pathway (3716); , Pathway (3716)

ncbi summary :

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq, Jul 2008]

uniprot summary :

JAK1: a widely expressed non-receptor tyrosine-kinase involved in the interferon-alpha/beta and -gamma signal transduction pathways. Couples cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. A selective Jak1 inhibitor induces apoptosis in NRP-154 prostate cancer cell line. A single mutation seen in tyrosine kinome screen of colon cancers. Activated in B cell lines from patients with post-transplant lymphoproliferative disorder, and in a mouse Lck-driven T cell lymphoma. Inhibitor: Piceatannol. Protein type: Kinase, protein; Protein kinase, TK; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); TK group; JakA family. Chromosomal Location of Human Ortholog: 1p32.3-p31.3. Cellular Component: extrinsic to internal side of plasma membrane; focal adhesion; cytoskeleton; cytoplasm; endomembrane system; cytosol; nucleus. Molecular Function: protein binding; growth hormone receptor binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; protein phosphatase binding; ATP binding; CCR5 chemokine receptor binding. Biological Process: response to antibiotic; cell migration; cytokine and chemokine mediated signaling pathway; innate immune response; cell differentiation; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage