ITGA2 Antibody (C-term) | MyBioSource MBS9205226 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ITGA2 Antibody (C-term)

catalog :

MBS9205226

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Anti-ITGA2 Antibody (C-term) at 1:1000 dilution + A431 whole cell lysate Lysates/proteins at 20 ?g per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 129 kDa Blocking/Dilution buffer: 5% NFDM/TBST

image 2 :

Western blot analysis of ITGA2 Antibody (C-term) in MDA-MB231 cell line lysates (35ug/lane). ITGA2 (arrow) was detected using the purified Pab.

product information

catalog number :

MBS9205226

products type :

Antibody

products full name :

ITGA2 Antibody (C-term)

products short name :

[ITGA2]

products name syn :

[Integrin alpha-2; CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha; CD49b; ITGA2; CD49B]

other names :

[integrin alpha-2; Integrin alpha-2; integrin alpha-2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha; CD_antigen: CD49b]

products gene name :

[ITGA2]

other gene names :

[ITGA2; ITGA2; BR; GPIa; CD49B; HPA-5; VLA-2; VLAA2; CD49B; GPIa]

uniprot entry name :

ITA2_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human

sequence positions :

[1023-1049]

sequence length :

1181

specificity :

This ITGA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1023-1049 amino acids from the C-terminal region of human ITGA2.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB~~1:1000

image1 heading :

Testing Data (TD)

image2 heading :

Western Blot (WB)

other info1 :

Calculated MW: 129295

other info2 :

Function: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Cellular Location: Membrane; Single-pass type I membrane protein

products categories :

Cancer; Immunology; Microbiology

products description :

ITGA2 id a protein that belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.

products references :

Ye,F., Hu,G., et.al., J. Cell Biol. 188 (1), 157-173 (2010). Jokinen,J., et.al., EMBO J. 29 (1), 196-208 (2010)

ncbi gi num :

116295258

ncbi acc num :

NP_002194.2

ncbi gb acc num :

NM_002203.3

uniprot acc num :

P17301

ncbi pathways :

, Pathway (3673); , Pathway (3673); , Pathway (3673); , Pathway (3673); , Pathway (3673); , Pathway (3673); , Pathway (3673); , Pathway (3673); , Pathway (3673); , Pathway (3673)

ncbi summary :

This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

uniprot summary :

ITGA2: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Belongs to the integrin alpha chain family. Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis; Receptor, misc. Chromosomal Location of Human Ortholog: 5q11.2. Cellular Component: cell surface; focal adhesion; perinuclear region of cytoplasm; plasma membrane; nerve terminal; integrin complex; nucleus; external side of plasma membrane. Molecular Function: viral receptor activity; collagen binding; integrin binding; protein binding; protein heterodimerization activity; metal ion binding; laminin binding. Biological Process: axon guidance; extracellular matrix organization and biogenesis; entry of virus into host cell; response to muscle activity; positive regulation of cell adhesion; positive regulation of positive chemotaxis; positive regulation of translation; positive regulation of smooth muscle cell proliferation; positive regulation of leukocyte migration; cell-matrix adhesion; positive regulation of collagen biosynthetic process; positive regulation of collagen binding; positive regulation of cell projection organization and biogenesis; mesodermal cell differentiation; positive regulation of smooth muscle cell migration; response to organic cyclic substance; response to L-ascorbic acid; establishment of protein localization; mammary gland development; positive regulation of smooth muscle contraction; cell adhesion; positive regulation of DNA binding; integrin-mediated signaling pathway; response to drug; substrate-bound cell migration; skin morphogenesis; hypotonic response; cell-substrate adhesion; cellular response to hormone stimulus; detection of mechanical stimulus involved in sensory perception of pain; cell proliferation; organ morphogenesis; response to hypoxia; cell adhesion mediated by integrin; positive regulation of phagocytosis, engulfment; blood coagulation; positive regulation of inflammatory response; response to amine stimulus; positive regulation of transmission of nerve impulse. Disease: Bleeding Disorder, Platelet-type, 9

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage