product summary
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company name :
MyBioSource
product type :
antibody
product name :
GSDMA Antibody (N-term)
catalog :
MBS9204709
quantity :
0.08 mL
price :
165 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, flow cytometry, FACS, enzyme immunoassay, immunohistochemistry - paraffin section
more info or order :
image
image 1 :
Western blot analysis of GSDMA Antibody (N-term) in mouse liver tissue lysates (35ug/lane). GSDMA (arrow) was detected using the purified Pab.
image 2 :
GSDMA Antibody (N-term) IHC analysis in formalin fixed and paraffin embedded human skin carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GSDMA Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
image 3 :
GSDMA Antibody (N-term) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
product information
catalog number :
MBS9204709
products type :
Antibody
products full name :
GSDMA Antibody (N-term)
products short name :
[GSDMA]
products name syn :
[Gasdermin-A; Gasdermin-1; GSDMA; GSDM; GSDM1]
other names :
[gasdermin-A; Gasdermin-A; gasdermin-A; gasdermin A; Gasdermin-1]
products gene name :
[GSDMA]
other gene names :
[GSDMA; GSDMA; GSDM; FKSG9; GSDM1; GSDM; GSDM1]
uniprot entry name :
GSDMA_HUMAN
clonality :
Polyclonal
isotype :
Rabbit Ig
host :
Rabbit
reactivity :
Human, Mouse
sequence positions :
[66-94]
sequence length :
445
specificity :
This GSDMA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human GSDMA.
purity :
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
form :
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
storage stability :
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
tested application :
Western Blot (WB), ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P), Flow Cytometry (FC/FACS)
app notes :
WB~~1:1000. IHC-P~~1:50~100. FC~~1:10~50
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
image3 heading :
Flow Cytometry (FC/FACS)
other info2 :
Cellular Location: Cytoplasm, perinuclear region. Cytoplasm, cytosol {ECO:0000250 UniProtKB:P57764}. Cell membrane {ECO:0000250 UniProtKB:P57764}. Tissue Location: Expressed predominantly in the gastrointestinal tract and, at a lower level, in the skin. Also detected in mammary gland. In the gastrointestinal tract, mainly expressed in differentiated cells, including the differentiated cell layer of esophagus and mucus-secreting pit cells of the gastric epithelium. Down-regulateded in gastric cancer cells.
products categories :
Cell Biology
products description :
Background: GSDMA induces apoptosis. Function: May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed: 27281216 ). The physiological relevance of these observations is unknown (Probable).
products references :
Soranzo, N., et al. Nat. Genet. 41(11):1182-1190(2009). Saeki, N., et al. Genes Chromosomes Cancer 48(3):261-271(2009). Tamura, M., et al. Genomics 89(5):618-629(2007)
ncbi gi num :
150456463
ncbi acc num :
NP_835465.2
ncbi gb acc num :
NM_178171.4
uniprot acc num :
Q96QA5
ncbi mol weight :
49365
uniprot summary :
GSDMA: Induces apoptosis. Belongs to the gasdermin family. Protein type: Apoptosis. Chromosomal Location of Human Ortholog: 17q21.1. Cellular Component: perinuclear region of cytoplasm. Biological Process: apoptosis
size1 :
0.08 mL
price1 :
165 USD
size2 :
0.4 mL
price2 :
370
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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