PCDHGC5 Antibody (Center) | MyBioSource MBS9204539 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PCDHGC5 Antibody (Center)

catalog :

MBS9204539

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, enzyme immunoassay, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

image

image 1 :

PCDHGC5 Antibody (Center) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the PCDHGC5 antibody detected the PCDHGC5 protein (arrow).

image 2 :

PCDHGC5 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PCDHGC5 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

product information

catalog number :

MBS9204539

products type :

Antibody

products full name :

PCDHGC5 Antibody (Center)

products short name :

[PCDHGC5]

products name syn :

[Protocadherin gamma-C5; PCDH-gamma-C5; PCDHGC5]

other names :

[protocadherin gamma-C5 isoform 1; Protocadherin gamma-C5; protocadherin gamma-C5; protocadherin gamma subfamily C, 5]

products gene name :

[PCDHGC5]

other gene names :

[PCDHGC5; PCDHGC5; PCDH-GAMMA-C5; PCDH-gamma-C5]

uniprot entry name :

PCDGM_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Mouse

sequence positions :

[499-526]

specificity :

This PCDHGC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 499-526 amino acids from the Central region of human PCDHGC5.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P)

app notes :

WB~~1:1000. IHC-P~~1:10~50

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

other info2 :

Cellular Location: Cell membrane; Single-pass type I membrane protein

products categories :

Neuroscience; Signal Transduction

products description :

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes,subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

products references :

Wu, Q., et al. Genome Res. 11(3):389-404(2001). Nollet, F., et al. J. Mol. Biol. 299(3):551-572(2000). Yagi, T., et al. Genes Dev. 14(10):1169-1180(2000). Wu, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 97(7):3124-3129(2000). Wu, Q., et al. Cell 97(6):779-790(1999)

ncbi gi num :

11128023

ncbi acc num :

NP_061752.1

ncbi gb acc num :

NM_018929.2

uniprot acc num :

Q9Y5F6

ncbi summary :

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

uniprot summary :

PCDHGC5: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 5q31. Cellular Component: integral to membrane; plasma membrane. Molecular Function: calcium ion binding. Biological Process: homophilic cell adhesion

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage