TRIM38 Antibody (C-term) | MyBioSource MBS9204523 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

TRIM38 Antibody (C-term)

catalog :

MBS9204523

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, cow

application :

western blot, ELISA, immunohistochemistry, flow cytometry, FACS, enzyme immunoassay, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

image

image 1 :

TRIM38 Antibody (C-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the TRIM38 antibody detected the TRIM38 protein (arrow).

image 2 :

TRIM38 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TRIM38 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

image 3 :

TRIM38 Antibody (C-term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

product information

catalog number :

MBS9204523

products type :

Antibody

products full name :

TRIM38 Antibody (C-term)

products short name :

[TRIM38]

products name syn :

[E3 ubiquitin-protein ligase TRIM38; 632-; RING finger protein 15; Tripartite motif-containing protein 38; Zinc finger protein RoRet; TRIM38; RNF15; RORET]

other names :

[E3 ubiquitin-protein ligase TRIM38; E3 ubiquitin-protein ligase TRIM38; E3 ubiquitin-protein ligase TRIM38; tripartite motif containing 38; RING finger protein 15; Tripartite motif-containing protein 38; Zinc finger protein RoRet]

products gene name :

[TRIM38]

other gene names :

[TRIM38; TRIM38; RNF15; RORET; RNF15; RORET]

uniprot entry name :

TRI38_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human (Predicted Reactivity: Bovine)

sequence positions :

[423-451]

sequence length :

465

specificity :

This TRIM38 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 423-451 amino acids from the C-terminal region of human TRIM38.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC-P), Flow Cytometry (FC/FACS)

app notes :

WB~~1:1000. IHC-P~~1:10~50. FC~~1:10~50

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Flow Cytometry (FC/FACS)

other info1 :

Function: E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAm1, inhibiting TLR3-mediated type I interferon signaling. Tissue Location: Ubiquitous

products description :

The protein encoded by this gene is a member of the. tripartite motif (TRIM) family. The TRIM motif includes three. zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,. and a coiled-coil region. The function of this protein has not been. identified.

products references :

Benyamin, B., et al. Am. J. Hum. Genet. 84(1):60-65(2009). Matsuda, A., et al. Oncogene 22(21):3307-3318(2003). Chen, D., et al. J. Biol. Chem. 277(18):15985-15991(2002). Reymond, A., et al. EMBO J. 20(9):2140-2151(2001). Ruddy, D.A., et al. Genome Res. 7(5):441-456(1997)

ncbi gi num :

5454014

ncbi acc num :

NP_006346.1

ncbi gb acc num :

NM_006355.4

uniprot acc num :

O00635

ncbi mol weight :

53416

ncbi pathways :

Pentose And Glucuronate Interconversions Pathway (10475); Pentose And Glucuronate Interconversions Pathway (10475); Pentose And Glucuronate Interconversions Pathway (10475); Pentose And Glucuronate Interconversions Pathway (10475)

ncbi summary :

This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012]

uniprot summary :

TRIM38: E3 ubiquitin-protein ligase. Mediates Lys-48 -linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling. {ECO:0000269 PubMed:23056470}. Protein type: Ubiquitin conjugating system. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: cytosol. Molecular Function: signal transducer activity; zinc ion binding; ligase activity. Biological Process: proteasomal ubiquitin-dependent protein catabolic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of viral genome replication; positive regulation of virion penetration into host cell; cytokine and chemokine mediated signaling pathway; positive regulation of transcription factor activity; regulation of interferon-beta production; negative regulation of defense response to virus; activation of NF-kappaB transcription factor

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage