PRDX1 Antibody (Center) | MyBioSource MBS9203640 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PRDX1 Antibody (Center)

catalog :

MBS9203640

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, ELISA, flow cytometry, FACS, enzyme immunoassay, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of PRDX1 Antibody (Center) in CEM cell line lysates (35ug/lane). PRDX1 (arrow) was detected using the purified Pab.

image 2 :

Western blot analysis of PRDX1 (arrow) using rabbit polyclonal PRDX1 Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PRDX1 gene (Lane 2).

image 3 :

PRDX1 Antibody (Center) flow cytometric analysis of 293 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

product information

catalog number :

MBS9203640

products type :

Antibody

products full name :

PRDX1 Antibody (Center)

products short name :

[PRDX1]

products name syn :

[Peroxiredoxin-1; Natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2; PRDX1; PAGA; PAGB; TDPX2]

other names :

[peroxiredoxin-1; Peroxiredoxin-1; peroxiredoxin-1; peroxiredoxin 1; Natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2]

products gene name :

[PRDX1]

other gene names :

[PRDX1; PRDX1; PAG; PAGA; PAGB; PRX1; PRXI; MSP23; NKEFA; TDPX2; NKEF-A; PAGA; PAGB; TDPX2; NKEF-A; PAG]

uniprot entry name :

PRDX1_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human (Predicted Reactivity: Hamster, Rat)

sequence positions :

[88-116]

specificity :

This PRDX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-116 amino acids from the Central region of human PRDX1.

purity :

Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

storage stability :

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry-Paraffin (IHC-P)

app notes :

WB~~1:1000. FC~~1:10~50. IHC-P~~1:50~100

image1 heading :

Western Blot (WB)

image2 heading :

Western Blot (WB)

image3 heading :

Flow Cytometry (FC/FACS)

image4 heading :

Immunohistochemistry (IHC)

image4 description :

PRDX1 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PRDX1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

other info1 :

Function: Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).

other info2 :

Cellular Location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

products categories :

Cancer; Cardiovascular; Cell Biology; Metabolism; Signal Transduction

products description :

PRDX1 is a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. This protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression.

products references :

Song,I.S., et.al., Carcinogenesis 30 (7), 1106-1114 (2009)

ncbi gi num :

320461711

ncbi acc num :

NP_001189360.1

ncbi gb acc num :

NM_001202431.1

uniprot acc num :

Q06830

ncbi mol weight :

22110

ncbi summary :

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]

uniprot summary :

PRDX1: a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). May have a proliferative effect and play a role in cancer development or progression. Protein type: Oxidoreductase; Nuclear receptor co-regulator; EC 1.11.1.15. Chromosomal Location of Human Ortholog: 1p34.1. Cellular Component: peroxisomal matrix; extracellular space; mitochondrial matrix; cytoplasm; nucleolus; melanosome; cytosol; nucleus. Molecular Function: protein binding; peroxidase activity; protein homodimerization activity; thioredoxin peroxidase activity; heme binding. Biological Process: erythrocyte homeostasis; retinal homeostasis; cell proliferation; regulation of stress-activated MAPK cascade; response to reactive oxygen species; removal of superoxide radicals; natural killer cell mediated cytotoxicity; hydrogen peroxide catabolic process; skeletal development; regulation of NF-kappaB import into nucleus

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage