PDGFD Antibody | MyBioSource MBS9203460 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PDGFD Antibody

catalog :

MBS9203460

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of lysate from mouse kidney tissue lysate, using PDGFD Antibody. MBS9203460 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.

product information

catalog number :

MBS9203460

products type :

Antibody

products full name :

PDGFD Antibody

products short name :

[PDGFD]

products name syn :

[Platelet-derived growth factor D; PDGF-D; Iris-expressed growth factor; Spinal cord-derived growth factor B; SCDGF-B; Platelet-derived growth factor D; latent form; PDGFD latent form; Platelet-derived growth factor D; receptor-binding form; PDGFD receptor-binding form; PDGFD; IEGF; SCDGFB]

other names :

[platelet-derived growth factor D isoform 1; Platelet-derived growth factor D; platelet-derived growth factor D; platelet derived growth factor D; Iris-expressed growth factor; Spinal cord-derived growth factor B; SCDGF-B]

products gene name :

[PDGFD]

other gene names :

[PDGFD; PDGFD; IEGF; SCDGFB; MSTP036; SCDGF-B; IEGF; SCDGFB; PDGF-D; SCDGF-B; PDGFD latent form; PDGFD receptor-binding form]

uniprot entry name :

PDGFD_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Mouse

sequence length :

364

specificity :

This PDGFD antibody is generated from a rabbit immunized with a recombinant protein of human PDGFD.

purity :

Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB~~1:1000

image1 heading :

Western Blot (WB)

other info1 :

Calculated MW: 42848

other info2 :

Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). Cellular location: Secreted. Note=Released by platelets upon wounding. Tissue location: Tissue Location Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate,testis, small intestine, spleen and colon. Inthe kidney, expressed by the visceralepithelial cells of the glomeruli. A widespreadexpression is also seen in the medial smoothmuscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae inthe medullary area Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of atherosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines.

products categories :

Cancer; Cardiovascular; Neuroscience; Signal Transduction

products description :

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity).

products references :

Hamada T.,et al.Biochem. Biophys. Res. Commun. 280:733-737(2001). Bergsten E.,et al.Nat. Cell Biol. 3:512-516(2001). LaRochelle W.J.,et al.Nat. Cell Biol. 3:517-521(2001). Wistow G.,et al.Mol. Vis. 8:185-195(2002). Liu B.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.

ncbi gi num :

13376808

ncbi acc num :

NP_079484.1

ncbi gb acc num :

NM_025208.4

uniprot acc num :

Q9GZP0

ncbi pathways :

Xylene Degradation Pathway (80310); Xylene Degradation Pathway (80310); Xylene Degradation Pathway (80310); Xylene Degradation Pathway (80310); Xylene Degradation Pathway (80310); Xylene Degradation Pathway (80310); Xylene Degradation Pathway (80310); Xylene Degradation Pathway (80310); Xylene Degradation Pathway (80310); Xylene Degradation Pathway (80310)

ncbi summary :

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

PDGFD: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide; Oncoprotein. Chromosomal Location of Human Ortholog: 11q22.3. Cellular Component: Golgi membrane; endoplasmic reticulum lumen; extracellular region. Molecular Function: growth factor activity; platelet-derived growth factor receptor binding. Biological Process: multicellular organismal development; positive regulation of cell division; platelet-derived growth factor receptor signaling pathway; regulation of peptidyl-tyrosine phosphorylation

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage