FCER1G Antibody (C-term) | MyBioSource MBS9203246 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

FCER1G Antibody (C-term)

catalog :

MBS9203246

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemical analysis of paraffin-embedded H. spleen section using FCER1G Antibody (C-term). MBS9203246 was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.

image 2 :

Western blot analysis of lysate from human spleen tissue lysate, using FCER1G Antibody (C-term). MBS9203246 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.

image 3 :

product information

catalog number :

MBS9203246

products type :

Antibody

products full name :

FCER1G Antibody (C-term)

products short name :

[FCER1G]

products name syn :

[High affinity immunoglobulin epsilon receptor subunit gamma; Fc receptor gamma-chain; FcRgamma; Fc-epsilon RI-gamma; IgE Fc receptor subunit gamma; FceRI gamma; FCER1G]

other names :

[high affinity immunoglobulin epsilon receptor subunit gamma; High affinity immunoglobulin epsilon receptor subunit gamma; high affinity immunoglobulin epsilon receptor subunit gamma; Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide; Fc receptor gamma-chain; FcRgamma; Fc-epsilon RI-gamma; IgE Fc receptor subunit gamma; FceRI gamma]

products gene name :

[FCER1G]

other gene names :

[FCER1G; FCER1G; FCRG; FcRgamma; FceRI gamma]

uniprot entry name :

FCERG_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human (Predicted Reactivity: Bovine, Monkey, Mouse, Pig, Rat)

specificity :

This FCER1G antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-86 amino acids from the C-terminal region of human FCER1G.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

tested application :

ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P), Western Blot (WB)

app notes :

IHC~~1:25. WB~~1:1000

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Western Blot (WB)

image3 heading :

Western Blot (WB)

other info1 :

Function: Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin.

other info2 :

Cellular Location: Cell membrane; Single-pass type I membrane protein

products categories :

Immunology

products description :

The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors

products references :

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Han, S., et al. Hum. Immunol. 71(7):727-730(2010). Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010). Davila, S., et al. Genes Immun. 11(3):232-238(2010). Untersmayr, E., et al. PLoS ONE 5 (2), E9023 (2010) :

ncbi gi num :

4758344

ncbi acc num :

NP_004097.1

ncbi gb acc num :

NM_004106.1

uniprot acc num :

P30273

ncbi mol weight :

9667

ncbi pathways :

Pantothenate And CoA Biosynthesis Pathway (2207); Pantothenate And CoA Biosynthesis Pathway (2207); Pantothenate And CoA Biosynthesis Pathway (2207); Pantothenate And CoA Biosynthesis Pathway (2207); Pantothenate And CoA Biosynthesis Pathway (2207); Pantothenate And CoA Biosynthesis Pathway (2207); Pantothenate And CoA Biosynthesis Pathway (2207); Pantothenate And CoA Biosynthesis Pathway (2207); Pantothenate And CoA Biosynthesis Pathway (2207); Pantothenate And CoA Biosynthesis Pathway (2207)

ncbi summary :

uniprot summary :

FCER1G: Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin. Belongs to the CD3Z/FCER1G family. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1q23. Cellular Component: cell surface; integral to plasma membrane; Fc-epsilon receptor I complex; plasma membrane; external side of plasma membrane. Molecular Function: protein binding; IgG binding; IgE binding; IgE receptor activity. Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; mast cell activation; positive regulation of interleukin-10 production; negative regulation of mast cell apoptosis; positive regulation of phagocytosis; antigen processing and presentation of exogenous peptide antigen via MHC class I; Fc receptor mediated stimulatory signaling pathway; integrin-mediated signaling pathway; neutrophil chemotaxis; platelet activation; positive regulation of type I hypersensitivity; positive regulation of interleukin-6 production; positive regulation of mast cell degranulation; positive regulation of type III hypersensitivity; positive regulation of tumor necrosis factor production; neutrophil activation during immune response; serotonin secretion by platelet; positive regulation of type IIa hypersensitivity; defense response to bacterium; innate immune response; positive regulation of mast cell cytokine production; immunoglobulin mediated immune response; phagocytosis, engulfment; blood coagulation; leukocyte migration

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage