MMP24 Antibody (Center) | MyBioSource MBS9202434 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MMP24 Antibody (Center)

catalog :

MBS9202434

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, ELISA, enzyme immunoassay, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of MMP24 Antibody (Center) in HL60 cell line lysates (35ug/lane). MMP24 (arrow) was detected using the purified Pab.

image 2 :

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

product information

catalog number :

MBS9202434

products type :

Antibody

products full name :

MMP24 Antibody (Center)

products short name :

[MMP24]

products name syn :

[Matrix metalloproteinase-24; MMP-24; 3424-; Membrane-type matrix metalloproteinase 5; MT-MMP 5; MTMMP5; Membrane-type-5 matrix metalloproteinase; MT5-MMP; MT5MMP; Processed matrix metalloproteinase-24; MMP24; MT5MMP]

other names :

[matrix metalloproteinase-24 preproprotein; Matrix metalloproteinase-24; matrix metalloproteinase-24; matrix metallopeptidase 24 (membrane-inserted); Membrane-type matrix metalloproteinase 5; MT-MMP 5; MTMMP5]

products gene name :

[MMP24]

other gene names :

[MMP24; MMP24; MMP25; MMP-24; MT5MMP; MTMMP5; MT-MMP5; MT5-MMP; MT-MMP 5; MT5MMP; MMP-24; MT-MMP 5; MTMMP5; MT5-MMP; MT5MMP]

uniprot entry name :

MMP24_HUMAN

clonality :

Polyclonal

isotype :

host :

Rabbit

reactivity :

Human. Predicted: Mouse, Rat

sequence positions :

[396-425]

sequence length :

645

specificity :

This MMP24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-425 amino acids from the Central region of human MMP24.

purity :

Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

storage stability :

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P)

app notes :

WB~~1:1000. IHC-P~~1:50~100

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Function: Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity). Cellular Location: Matrix metalloproteinase-24: Cell membrane; Single-pass type I membrane protein Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Recycled back to the plasma membrane through the trans-Golgi network via interaction with APBA3. Tissue Location: Predominantly expressed in brain, kidney,pancreas and lung. Overexpressed in a seriesof brain tumors, including astrocytomas and glioblastomas

other info2 :

Calculated MW: 73231

products categories :

Cancer; Cell Biology; Neuroscience; Signal Transduction

products description :

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP24 is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed matrix metalloproteinase 24 (MMP24).

products references :

Jung, M., et al., Prostate 55(2):89-98 (2003). Kajita, M., et al., FEBS Lett. 457(3):353-356 (1999). Llano, E., et al., Cancer Res. 59(11):2570-2576 (1999). Nagase, H., et al., J. Biol. Chem. 274(31):21491-21494 (1999). Kinoh, H., et al., Cytogenet. Cell Genet. 87 (1-2), 97-98 (1999).

ncbi gi num :

5729929

ncbi acc num :

NP_006681.1

ncbi gb acc num :

NM_006690.3

uniprot acc num :

Q9Y5R2

ncbi summary :

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. [provided by RefSeq, Jul 2008]

uniprot summary :

MMP24: Activates progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin. Belongs to the peptidase M10A family. Protein type: Activator; EC 3.4.24.-; Protease; Membrane protein, integral. Chromosomal Location of Human Ortholog: 20q11.2. Cellular Component: proteinaceous extracellular matrix; integral to plasma membrane; trans-Golgi network membrane. Molecular Function: zinc ion binding; cadherin binding; metalloendopeptidase activity; enzyme activator activity; calcium ion binding. Biological Process: positive regulation of catalytic activity; glial cell differentiation; proteolysis; detection of temperature stimulus involved in sensory perception of pain

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage