HIST1H2BJ/HIST1H2BK/HIST3H2BB Antibody (C-term) | MyBioSource MBS9201580 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

HIST1H2BJ/HIST1H2BK/HIST3H2BB Antibody (C-term)

catalog :

MBS9201580

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, cow

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

HIST1H2BJ/HIST1H2BK/HIST3H2BB Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the HIST1H2BJ/HIST1H2BK/HIST3H2BB antibody detected the HIST1H2BJ/HIST1H2BK/HIST3H2BB protein (arrow).

product information

catalog number :

MBS9201580

products type :

Antibody

products full name :

HIST1H2BJ/HIST1H2BK/HIST3H2BB Antibody (C-term)

products short name :

[HIST1H2BJ/HIST1H2BK/HIST3H2BB]

products name syn :

[Histone H2B type 1-J; Histone H2B1; Histone H2Br; H2B/r; HIST1H2BJ; H2BFR]

other names :

[histone H2B type 1-J; Histone H2B type 1-J; histone H2B type 1-J; histone cluster 1, H2bj; Histone H2B.1; Histone H2B.r; H2B/r]

products gene name :

[HIST1H2BJ]

other gene names :

[HIST1H2BJ; HIST1H2BJ; H2BJ; H2B/r; H2BFR; H2BFR; H2B/r]

uniprot entry name :

H2B1J_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human (Predicted Reactivity: Xenopus, Bovine, Monkey, Mouse)

sequence positions :

[98-126]

sequence length :

126

specificity :

This HIST1H2BJ/HIST1H2BK/HIST3H2BB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-126 amino acids from the C-terminal region of human HIST1H2BJ/HIST1H2BK/HIST3H2BB.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB~~1:1000

image1 heading :

Western Blot (WB)

other info1 :

Calculated MW: 13904

other info2 :

Function: Core component of nucleosome.Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to thecellular machineries which require DNA as atemplate. Histones thereby play a central rolein transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

products description :

Histones are basic nuclear proteins that are responsible. for the nucleosome structure of the chromosomal fiber in. eukaryotes. Two molecules of each of the four core histones (H2A,. H2B, H3, and H4) form an octamer, around which approximately 146 bp. of DNA is wrapped in repeating units, called nucleosomes. The. linker histone, H1, interacts with linker DNA between nucleosomes. and functions in the compaction of chromatin into higher order. structures. This gene is intronless and encodes a member of the. histone H2B family. Transcripts from this gene lack polyA tails but. instead contain a palindromic termination element. This gene is. found in the histone microcluster on chromosome 6p21.33. [provided. by RefSeq].

products references :

Shi, J., et al. Nature 460(7256):753-757(2009). Benyamin, B., et al. Am. J. Hum. Genet. 84(1):60-65(2009). Kim, S.C., et al. Mol. Cell 23(4):607-618(2006). Beck, H.C., et al. Mol. Cell Proteomics 5(7):1314-1325(2006). Pavri, R., et al. Cell 125(4):703-717(2006)

ncbi gi num :

20336754

ncbi acc num :

NP_066402.2

ncbi gb acc num :

NM_021058.3

uniprot acc num :

P06899

ncbi summary :

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Jul 2008]

uniprot summary :

HIST1H2BJ: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H2B family. Chromosomal Location of Human Ortholog: 6p22.1. Cellular Component: nucleoplasm; extracellular space; nucleosome; nucleus. Molecular Function: DNA binding; protein heterodimerization activity. Biological Process: nucleosome assembly; defense response to Gram-positive bacterium; establishment and/or maintenance of chromatin architecture; innate immune response in mucosa; antibacterial humoral response

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage