Phospho-MAP4K1 (S171) Antibody | MyBioSource MBS9201545 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Phospho-MAP4K1 (S171) Antibody

catalog :

MBS9201545

quantity :

0.08 mL

price :

155 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9201545

products type :

Antibody

products full name :

Phospho-MAP4K1 (S171) Antibody

products short name :

Phospho-MAP4K1 (S171)

products name syn :

Mitogen-activated protein kinase kinase kinase kinase 1; Hematopoietic progenitor kinase; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; MAP4K1; HPK1

other names :

mitogen-activated protein kinase kinase kinase kinase 1 isoform 1; Mitogen-activated protein kinase kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase kinase 1; Hematopoietic progenitor kinase; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1

products gene name :

MAP4K1

other gene names :

MAP4K1; MAP4K1; HPK1; HPK1; MEK kinase kinase 1; MEKKK 1

uniprot entry name :

M4K1_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human (Predicted Reactivity: Mouse)

sequence length :

821

specificity :

This MAP4K1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S171 of human MAP4K1.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

concentration :

Vial Concentration: 0.34

storage stability :

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

tested application :

Dot Blot (DB), ELISA (EIA)

app notes :

DB~~1:500

other info1 :

Antigen Type: Synthetic Peptide

other info2 :

Antigen Source: HUMAN

products categories :

Signal Transduction; Phospho Antibodies

products description :

The c-Jun amino-terminal kinases (JNKs)/stress-activated protein kinases (SAPKs) play a crucial role in stress responses in mammalian cells. The mechanism underlying this pathway in the hematopoietic system is unclear, but it is a key in understanding the molecular basis of blood cell differentiation. We have cloned a novel protein kinase, termed hematopoietic progenitor kinase 1 (HPK1), that is expressed predominantly in hematopoietic cells, including early progenitor cells. HPK1 is related distantly to the p21(Cdc42/Rac1)-activated kinase (PAK) and yeast STE20 implicated in the mitogen-activated protein kinase (MAPK) cascade. Expression of HPK1 activates JNK1 specifically, and it elevates strongly AP-1-mediated transcriptional activity in vivo. HPK1 binds and phosphorylates MEKK1 directly, whereas JNK1 activation by HPK1 is inhibited by a dominant-negative MEKK1 or MKK4/SEK mutant. Interestingly, unlike PAK65, HPK1 does not contain the small GTPase Rac1/Cdc42-binding domain and does not bind to either Rac1 or Cdc42, suggesting that HPK1. activation is Rac1/Cdc42-independent. These results indicate that HPK1 is a novel functional activator of the JNK/SAPK signaling pathway.

products references :

Hu M.C.-T., Genes Dev. 10:2251-2264(1996). Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Wissing J., Mol. Cell. Proteomics 6:537-547(2007).

ncbi gi num :

110611908

ncbi acc num :

NP_001036065.1

ncbi gb acc num :

NM_001042600.2

uniprot acc num :

Q92918

ncbi mol weight :

91296

ncbi pathways :

Cyanoamino Acid Metabolism Pathway (11184); Cyanoamino Acid Metabolism Pathway (11184); Cyanoamino Acid Metabolism Pathway (11184); Cyanoamino Acid Metabolism Pathway (11184); Cyanoamino Acid Metabolism Pathway (11184); Cyanoamino Acid Metabolism Pathway (11184); Cyanoamino Acid Metabolism Pathway (11184); Cyanoamino Acid Metabolism Pathway (11184); Cyanoamino Acid Metabolism Pathway (11184); Cyanoamino Acid Metabolism Pathway (11184)

uniprot summary :

HPK1: a protein kinase of the STE20 family. Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. May play a role in hematopoietic lineage decisions and growth regulation. Positively regulated by PGE2 and a negative regulator of PGE2-induced FOS gene transcription. Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; EC 2.7.11.1; Kinase, protein; STE group; STE20 family; KHS subfamily. Chromosomal Location of Human Ortholog: 19q13.1-q13.4. Cellular Component: membrane; cytoplasm. Molecular Function: protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase kinase activity; ATP binding; protein kinase activity. Biological Process: cell proliferation; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; activation of MAPKKK activity; response to stress; protein amino acid phosphorylation; activation of JNK activity

size1 :

0.08 mL

price1 :

155 USD

size2 :

0.4 mL

price2 :

340

more info or order :

MyBioSource product webpage