catalog number :
MBS9201316
products full name :
(DANRE) srebf2 Antibody (Center)
products short name :
[srebf2]
products name syn :
[Sterol regulatory element-binding protein 2; SREBP-2; Sterol regulatory element-binding transcription factor 2; Processed sterol regulatory element-binding protein 2; srebf2 {ECO:0000250 UniProtKB:Q12772}]
other names :
[sterol regulatory element-binding protein 2; Sterol regulatory element-binding protein 2; sterol regulatory element-binding protein 2; sterol regulatory element binding transcription factor 2; Sterol regulatory element-binding transcription factor 2]
products gene name :
[srebf2]
other gene names :
[srebf2; srebf2; zgc:158371; SREBP-2]
uniprot entry name :
SRBP2_DANRE
specificity :
This (DANRE) srebf2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 441-473 amino acids from the Central region of human (DANRE) srebf2.
purity :
Purified Rabbit Polyclonal Antibody (Pab)
form :
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
storage stability :
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
tested application :
Western Blot (WB), ELISA (EIA)
image1 heading :
Western Blot (WB)
other info1 :
Cellular Location: Endoplasmic reticulum membrane
{ECO:0000250IUniProtKB:Q12772} ;
Multi-pass membrane protein
{ECO:0000250IUniProtKB:Q12772}. Golgi
apparatus membrane
{ECO:00002501 UniProtKB :012 772};
Multi-pass membrane protein
{ECO:0000250IUniProtKB:Q12772} .
Cytoplasmic vesicle, COPII-coated vesicle
membrane
{ECO:00002501 Uni ProtKB:012 772};
Multi-pass membrane protein
{ECO:0000250IUniProtKB:Q12772} .
Note=Moves from the endoplasmic reticulum
to the Golgi in the absence of sterols
{ECO:00002501 UniProtKB :012 772}
products description :
Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity).
ncbi acc num :
NP_001082935.1
ncbi gb acc num :
NM_001089466.1
uniprot summary :
Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes ().