DSCR1 Antibody (C-term) | MyBioSource MBS9200840 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

DSCR1 Antibody (C-term)

catalog :

MBS9200840

quantity :

0.08 mL

price :

155 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9200840

products type :

Antibody

products full name :

DSCR1 Antibody (C-term)

products short name :

DSCR1

products name syn :

Calcipressin-1; Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1; RCAN1; ADAPT78; CSP1; DSC1; DSCR1

other names :

calcipressin-1 isoform a; Calcipressin-1; calcipressin-1; regulator of calcineurin 1; Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1

products gene name :

RCAN1

other gene names :

RCAN1; RCAN1; CSP1; DSC1; RCN1; DSCR1; MCIP1; ADAPT78; ADAPT78; CSP1; DSC1; DSCR1; MCIP1

uniprot entry name :

RCAN1_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human (Predicted Reactivity: Bovine, Hamster, Mouse, Rat)

sequence positions :

222-252

sequence length :

252

specificity :

This DSCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-252 amino acids from the C-terminal region of human DSCR1.

purity :

Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

concentration :

Vial Concentration: 2

storage stability :

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB)

app notes :

WB~~1:1000

other info1 :

Antigen Type: Synthetic Peptide. Other Acession: O6IN33, O9JHG6, O35847, O3ZBP4, O7Z555, O6XXM7. Function: Inhibits calcineurin-dependent transciptional reponses by binding to the catalytic domain of calcineurin A. Could play a role during central nervouse system development. Tissue Location: Highly expressed in all other tissues.

other info2 :

Antigen Source: HUMAN

products categories :

Neuroscience

products description :

DSCR1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. The gene for this protein is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of DSCR1 may lead to neurofibrillary tangles such as those associated with Alzheimer disease.

products references :

Minami, T., et al., J. Biol. Chem. 279(48):50537-50554 (2004). Yao, Y.G., et al., Biochem. Biophys. Res. Commun. 321(3):648-656 (2004). Michtalik, H.J., et al., Free Radic. Biol. Med. 37(4):454-462 (2004). Hesser, B.A., et al., Blood 104(1):149-158 (2004). Iizuka, M., et al., Biochem. Biophys. Res. Commun. 41(4):334-344 (2004).

ncbi gi num :

33620725

ncbi acc num :

NP_004405.3

ncbi gb acc num :

NM_004414.6

uniprot acc num :

P53805

ncbi mol weight :

28079

ncbi pathways :

RNA Polymerase Pathway (1827); RNA Polymerase Pathway (1827); RNA Polymerase Pathway (1827); RNA Polymerase Pathway (1827); RNA Polymerase Pathway (1827); RNA Polymerase Pathway (1827); RNA Polymerase Pathway (1827)

ncbi summary :

Function Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Tissue Location Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues

uniprot summary :

RCAN1: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Interacts with RAF1. By calcium. Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues. Belongs to the RCAN family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Inhibitor. Chromosomal Location of Human Ortholog: 21q22.12. Cellular Component: cytoplasm; nucleus. Molecular Function: calcium-dependent protein serine/threonine phosphatase regulator activity; DNA binding; identical protein binding; nucleotide binding; protein binding; transcription factor activity. Biological Process: blood circulation; calcineurin-NFAT signaling pathway; central nervous system development; regulation of catalytic activity; regulation of transcription, DNA-dependent; signal transduction

size1 :

0.08 mL

price1 :

155 USD

size2 :

0.4 mL

price2 :

340

more info or order :

MyBioSource product webpage