AMHR2 Antibody (C-term) | MyBioSource MBS9200710 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

AMHR2 Antibody (C-term)

catalog :

MBS9200710

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, ELISA, flow cytometry, FACS, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of AMHR2 Antibody (C-term) in CEM cell line lysates (35ug/lane).AMHR2 (arrow) was detected using the purified Pab.

image 2 :

Flow cytometric analysis of CEM cells using AMHR2 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

image 3 :

Western blot analysis of AMHR2 Antibody (C-term) in CEM cell line lysates (35ug/lane).AMHR2 (arrow) was detected using the purified Pab.

product information

catalog number :

MBS9200710

products type :

Antibody

products full name :

AMHR2 Antibody (C-term)

products short name :

[AMHR2]

products name syn :

[Anti-Muellerian hormone type-2 receptor; Anti-Muellerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; MRII; AMHR2; AMHR; MISR2]

other names :

[anti-Muellerian hormone type-2 receptor isoform 2; Anti-Muellerian hormone type-2 receptor; anti-Muellerian hormone type-2 receptor; anti-Mullerian hormone receptor, type II; Anti-Muellerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; MRII]

products gene name :

[AMHR2]

other gene names :

[AMHR2; AMHR2; AMHR; MRII; MISR2; MISRII; AMHR; MISR2; AMH type II receptor; MISRII; MRII]

uniprot entry name :

AMHR2_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human (Predicted Reactivity: Mouse, Rat)

sequence positions :

[374-402]

sequence length :

478

specificity :

This AMHR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 374-402 amino acids from the C-terminal region of human AMHR2.

purity :

Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

storage stability :

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS)

app notes :

WB~~1:1000. FC~~1:10~50

image1 heading :

Western Blot (WB)

image2 heading :

Flow Cytometry (FC/FACS)

image3 heading :

Western Blot (WB)

image4 heading :

Flow Cytometry (FC/FACS)

image4 description :

products categories :

Signal Transduction

products description :

The AMH receptor (AMHR or AMHR2) is a serine/threonine kinase with a single transmembrane domain belonging to the family of type II receptors for TGF-beta-related proteins. Anti-Mullerian hormone (AMH) and its receptor are involved in the regression of Mullerian ducts in male fetuses. Male sex differentiation is mediated by 2 discrete hormones produced by the fetal testis. Testosterone, produced by Leydig cells, virilizes the external genitalia and promotes prostatic growth; anti-Mullerian hormone (AMH) results in regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes.

products references :

Picard, J.Y., et al., J. Soc. Biol. 196(3):217-221 (2002). Teixeira, J., et al., Endocr. Rev. 22(5):657-674 (2001). Imbeaud, S., et al., Nat. Genet. 11(4):382-388 (1995). Visser, J.A., et al., Biochem. Biophys. Res. Commun. 215(3):1029-1036 (1995). Sinisi, A.A., et al., J. Endocrinol. Invest. 26 (3 Suppl), 23-28 (2003).

ncbi gi num :

257743467

ncbi acc num :

NP_001158162.1

ncbi gb acc num :

NM_001164690.1

uniprot acc num :

Q16671

ncbi summary :

This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009]

uniprot summary :

MISR2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Protein type: Kinase, protein; Protein kinase, TKL; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; TKL group; STKR family; Type2 subfamily. Chromosomal Location of Human Ortholog: 12q13. Cellular Component: integral to plasma membrane. Molecular Function: protein binding; hormone binding; transforming growth factor beta receptor activity, type II; metal ion binding; receptor activity; ATP binding; receptor signaling protein serine/threonine kinase activity. Biological Process: Mullerian duct regression; transforming growth factor beta receptor signaling pathway; signal transduction; protein amino acid phosphorylation; sex differentiation. Disease: Persistent Mullerian Duct Syndrome, Types I And Ii

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage