ROR1 Antibody | MyBioSource MBS9200685 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ROR1 Antibody

catalog :

MBS9200685

quantity :

0.08 mL

price :

155 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, flow cytometry, FACS, enzyme immunoassay, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9200685

products type :

Antibody

products full name :

ROR1 Antibody

products short name :

ROR1

products name syn :

Tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophic tyrosine kinase; receptor-related 1; ROR1; NTRKR1

other names :

tyrosine-protein kinase transmembrane receptor ROR1 isoform 2; Tyrosine-protein kinase transmembrane receptor ROR1; tyrosine-protein kinase transmembrane receptor ROR1; receptor tyrosine kinase-like orphan receptor 1; Neurotrophic tyrosine kinase, receptor-related 1

products gene name :

ROR1

other gene names :

ROR1; ROR1; NTRKR1; dJ537F10.1; NTRKR1

uniprot entry name :

ROR1_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human, mouse

sequence length :

393

specificity :

This ROR1 antibody is generated from rabbits immunized with recombinant human ROR1 protein (aa region: 112 - 399).

purity :

Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry-Paraffin (IHC-P)

app notes :

IHC-P~~1:10~50. WB~~1:1000. FC~~1:25

other info1 :

Antigen Type: Recombinant Protein. Crown Antibody: Yes. Function: Tyrosine-protein kinase receptor whose role is not yet clear. Cellular Location : Membrane; Single-pass type I membrane protein. Tissue Location: Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm

other info2 :

Antigen Source: HUMAN

products categories :

Crown Antibodies; Neuroscience; Signal Transduction

products description :

ROR1 is a receptor protein tyrosine kinase whose cellular role has not been determined. It is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors. Studies of a similar protein in mouse suggest that this protein may interact with another receptor protein tyrosine kinase and may be involved in skeletal and cardiac development.

products references :

Nomi, M., et al., Mol. Cell. Biol. 21(24):8329-8335 (2001). Reddy, U.R., et al., Genomics 41(2):283-285 (1997). Reddy, U.R., et al., Oncogene 13(7):1555-1559 (1996). Masiakowski, P., et al., J. Biol. Chem. 267(36):26181-26190 (1992).

ncbi gi num :

134152686

ncbi acc num :

NP_001077061.1

ncbi gb acc num :

NM_001083592.1

uniprot acc num :

Q01973

ncbi mol weight :

104283

ncbi summary :

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

uniprot summary :

ROR1: Tyrosine-protein kinase receptor whose role is not yet clear. Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Kinase, protein; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; Ror family. Chromosomal Location of Human Ortholog: 1p31.3. Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; receptor complex. Molecular Function: Wnt-protein binding; protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding. Biological Process: peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway

size1 :

0.08 mL

price1 :

155 USD

size2 :

0.4 mL

price2 :

340

more info or order :

MyBioSource product webpage