LOX Antibody (Center) (Ascites) | MyBioSource MBS9200546 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

LOX Antibody (Center) (Ascites)

catalog :

MBS9200546

quantity :

0.1 mL

price :

370 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[624CT23.7.3]

reactivity :

human, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

LOX Antibody (Center)(Ascites) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the LOX antibody detected the LOX protein (arrow).

product information

catalog number :

MBS9200546

products type :

Antibody

products full name :

LOX Antibody (Center) (Ascites)

products short name :

[LOX]

products name syn :

[Protein-lysine 6-oxidase; Lysyl oxidase; LOX]

other names :

[protein-lysine 6-oxidase isoform 1 preproprotein; Protein-lysine 6-oxidase; protein-lysine 6-oxidase; lysyl oxidase; Lysyl oxidase]

products gene name :

[LOX]

other gene names :

[LOX; LOX]

uniprot entry name :

LYOX_HUMAN

clonality :

Monoclonal

isotype :

IgG2b

clone :

[624CT23.7.3]

host :

Mouse

reactivity :

Human (Predicted Reactivity: Mouse, Pig, Rat)

sequence positions :

[234-260]

sequence length :

417

specificity :

This LOX antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 234-260 amino acids from the Central region of human LOX.

form :

Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

storage stability :

Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB~~1:200~1600

image1 heading :

Western Blot (WB)

other info1 :

Antigen Type: Synthetic Peptide

other info2 :

Antigen Source: HUMAN. Function: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have adirect role in tumor suppression. Cellular Location: Secreted, extracellular space. Tissue Location: Heart, placenta, skeletal muscle, kidney, lung and pancreas.

products categories :

Cancer; Cardiovascular; Signal Transduction

products description :

The protein encoded by this gene is an extracellular. copper enzyme that initiates the crosslinking of collagens and. elastin. The enzyme catalyzes oxidative deamination of the. epsilon-amino group in certain lysine and hydroxylysine residues of. collagens and lysine residues of elastin. In addition to. crosslinking extracellular matrix proteins, the encoded protein may. have a role in tumor suppression. Defects in this gene are a cause. of autosomal recessive cutis laxa type I (CL type I). Two. transcript variants encoding different isoforms have been found for. this gene.

products references :

Gao, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 107(44):18892-18897(2010). Santhanam, A.N., et al. Oncogene 29(27):3921-3932(2010). Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :. Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) :

ncbi gi num :

20149540

ncbi acc num :

NP_002308.2

ncbi gb acc num :

NM_002317.5

uniprot acc num :

P28300

ncbi mol weight :

46944

ncbi summary :

The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

uniprot summary :

LOX: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Belongs to the lysyl oxidase family. Protein type: Secreted; Secreted, signal peptide; Oxidoreductase; EC 1.4.3.13. Chromosomal Location of Human Ortholog: 5q23.2. Cellular Component: proteinaceous extracellular matrix; extracellular space; collagen; extracellular region; nucleus. Molecular Function: protein binding; copper ion binding; protein-lysine 6-oxidase activity. Biological Process: response to drug; elastic fiber assembly; blood vessel development; extracellular matrix organization and biogenesis; collagen fibril organization; wound healing; response to steroid hormone stimulus; protein modification process; lung development. Disease: Cutis Laxa, Autosomal Recessive, Type Ia

size1 :

0.1 mL

price1 :

370 USD

more info or order :

MyBioSource product webpage