Human Collagen triple helix repeat-containing protein 1, CTHRC1 ELISA Kit | MyBioSource MBS919950 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Collagen triple helix repeat-containing protein 1, CTHRC1 ELISA Kit

catalog :

MBS919950

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS919950

products type :

ELISA Kit

products full name :

Human Collagen triple helix repeat-containing protein 1, CTHRC1 ELISA Kit

products short name :

collagen triple helix repeat containing 1

products name syn :

Human Collagen triple helix repeat-containing protein 1 (CTHRC1) ELISA kit; collagen triple helix repeat containing 1

other names :

collagen triple helix repeat-containing protein 1 isoform 2; Collagen triple helix repeat-containing protein 1; collagen triple helix repeat-containing protein 1; collagen triple helix repeat containing 1; Protein NMTC1

products gene name :

CTHRC1

other gene names :

CTHRC1; CTHRC1; UNQ762/PRO1550

uniprot entry name :

CTHR1_HUMAN

reactivity :

Human

sequence length :

229

specificity :

This assay has high sensitivity and excellent specificity for detection of Human CTHRC1. No significant cross-reactivity or interference between Human CTHRC1 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates. Assay Type: Sandwich. Detection Range: 6.25 ng/ml-400 ng/ml. Sensitivity: 1.56 ng/ml

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul

products description :

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for CTHRC1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any CTHRC1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for CTHRC1 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of CTHRC1 bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

368711292

ncbi acc num :

NP_001243028.1

ncbi gb acc num :

NM_001256099.1

uniprot acc num :

Q96CG8

ncbi mol weight :

26,224 Da

ncbi pathways :

Noncanonical Wnt Signaling Pathway (169354); Wnt Signaling Network Pathway (137962)

ncbi summary :

This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

uniprot summary :

CTHRC1: May act as a negative regulator of collagen matrix deposition. Defects in CTHRC1 may be a cause of Barrett esophagus (BE). A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Genetic variants in CTHRC1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 8q22.3. Cellular Component: proteinaceous extracellular matrix; extracellular space; collagen; cytoplasm. Molecular Function: Wnt-protein binding; frizzled binding. Biological Process: positive regulation of osteoblast differentiation; inner ear receptor stereocilium organization and biogenesis; cell migration; positive regulation of protein binding; Wnt receptor signaling pathway, planar cell polarity pathway; positive regulation of osteoblast proliferation. Disease: Barrett Esophagus

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage