Human Uncharacterized protein C9orf72, C9orf72 ELISA Kit | MyBioSource MBS918952 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Uncharacterized protein C9orf72, C9orf72 ELISA Kit

catalog :

MBS918952

quantity :

24-Strip-Wells (LIMIT 1)

price :

240 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS918952

products type :

ELISA Kit

products full name :

Human Uncharacterized protein C9orf72, C9orf72 ELISA Kit

products short name :

[chromosome 9 open reading frame 72]

products name syn :

[Human Uncharacterized protein C9orf72 (C9orf72) ELISA kit; MGC23980; RP11-27J8.2; OTTHUMP00000021172; hypothetical protein LOC203228; chromosome 9 open reading frame 72]

other names :

[protein C9orf72 isoform a; Protein C9orf72; protein C9orf72; chromosome 9 open reading frame 72]

products gene name :

[C9orf72]

other gene names :

[C9orf72; C9orf72; ALSFTD; FTDALS]

uniprot entry name :

CI072_HUMAN

reactivity :

Human

sequence length :

481

specificity :

This assay has high sensitivity and excellent specificity for detection of mouse C5a. No significant cross-reactivity or interference between mouse C5a and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Tissue Homogenates. Assay Type: Quantitative Sandwich. Detection Range: 39 pg/ml-2500 pg/ml. Sensitivity: 9.75 pg/ml.

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

products description :

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for C5a has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any C5a present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for C5a is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of C5a bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

365906244

ncbi acc num :

NP_001242983.1

ncbi gb acc num :

NM_001256054.1

uniprot acc num :

Q96LT7

ncbi mol weight :

24,759 Da

ncbi summary :

Expansion of a hexanucleotide repeat in non-coding sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

uniprot summary :

C9orf72: Defects in C9orf72 are the cause of frontotemporal dementia and/or amyotrophic lateral sclerosis (FTDALS). An autosomal dominant neurodegenerative disorder characterized by adult onset of frontotemporal dementia and/or amyotrophic lateral sclerosis in an affected individual. There is high intrafamilial variation. Frontotemporal dementia is characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Amyotrophic lateral sclerosis is characterized by the death of motor neurons in the brain, brainstem, and spinal cord, resulting in fatal paralysis. Caused by a large expansion of a GGGGCC hexanucleotide within the first C9orf72 intron located between the first and the second non-coding exons. The expansion leads to the loss of transcription of one of the two transcripts encoding isoform 1 and to the formation of nuclear RNA foci. 2 isoforms of the human protein are produced by alternative splicing. Chromosomal Location of Human Ortholog: 9p21.2. Cellular Component: nucleoplasm; extracellular space; intercellular bridge; lysosome; cytoplasm; autophagic vacuole; cytoplasmic vesicle; nucleus; endosome; actin cytoskeleton. Molecular Function: protein binding; Rab GTPase binding. Biological Process: autophagy; endocytosis. Disease: Frontotemporal Dementia And/or Amyotrophic Lateral Sclerosis 1

size1 :

24-Strip-Wells (LIMIT 1)

price1 :

240 USD

size2 :

48-Strip-Wells

price2 :

495

size3 :

96-Strip-Wells

price3 :

710

size4 :

5x96-Strip-Wells

price4 :

2705

size5 :

10x96-Strip-Wells

price5 :

5145

more info or order :

MyBioSource product webpage