product summary
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company name :
MyBioSource
product type :
antibody
product name :
HRH3 Polyclonal Antibody
catalog :
MBS9140883
quantity :
0.1 mL
price :
260 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, rat
application :
western blot
more info or order :
image
image 1 :
Western Blot analysis of extracts of rat brain, using HRH antibody (MBS9140883) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:1000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s
product information
catalog number :
MBS9140883
products type :
Antibody
products full name :
HRH3 Polyclonal Antibody
products short name :
[HRH3]
products name syn :
[HRH3; GPCR97; HH3R; histamine H3 receptor]
other names :
[histamine H3 receptor; Histamine H3 receptor; histamine H3 receptor; histamine receptor H3; G-protein coupled receptor 97]
products gene name :
[HRH3]
other gene names :
[HRH3; HRH3; HH3R; GPCR97; GPCR97; H3R; HH3R]
uniprot entry name :
HRH3_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Rat
sequence length :
445
purity :
Affinity Purification
form :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
storage stability :
Store at -20 degree C. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB: 1:500-1:2000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 250-350 of human HRH3 (NP_009163.2).
products description :
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system.
ncbi gi num :
194018562
ncbi acc num :
NP_009163.2
ncbi gb acc num :
NP_009163.2
uniprot acc num :
Q9Y5N1
ncbi mol weight :
Calculated: 36kDa; 40kDa; 45kDa; 47kDa; 48kDa; 49kDa. Observed: 49kDa
ncbi pathways :
Amine Ligand-binding Receptors Pathway (106363); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Histamine Receptors Pathway (106367); Monoamine Transport Pathway (198851); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462)
ncbi summary :
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008]
uniprot summary :
H3R: The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 niether modified adenylate cyclase activity nor induced intracellular calcium mobilization. Belongs to the G-protein coupled receptor 1 family. 7 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 20q13.33. Cellular Component: neuron projection; integral to plasma membrane; plasma membrane; myelin sheath. Molecular Function: drug binding; histamine receptor activity. Biological Process: negative regulation of glutamate secretion; eating behavior; neurotransmitter secretion; negative regulation of adenylate cyclase activity; negative regulation of gamma-aminobutyric acid secretion; drinking behavior; learning; regulation of norepinephrine secretion; response to organic cyclic substance; memory; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of serotonin secretion; elevation of cytosolic calcium ion concentration; negative regulation of blood pressure; brain development; positive regulation of epithelial cell proliferation
size1 :
0.1 mL
price1 :
260 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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