Mouse Integrin alpha-IIb, Itga2b/CD41 ELISA Kit | MyBioSource MBS913635 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse Integrin alpha-IIb, Itga2b/CD41 ELISA Kit

catalog :

MBS913635

quantity :

48-Strip-Wells

price :

510 USD

product information

catalog number :

MBS913635

products type :

ELISA Kit

products full name :

Mouse Integrin alpha-IIb, Itga2b/CD41 ELISA Kit

products short name :

Integrin alpha-IIb (Itga2b/CD41)

products name syn :

Mouse Integrin alpha-IIb (Itga2b/CD41) ELISA Kit; CD41; CD41B; GP2B; GPIIb; GTA; HPA3; integrin alpha 2b; platelet fibrinogen receptor; alpha subunit; platelet-specific antigen BAK; Integrin alpha-IIb (Itga2b/CD41)

other names :

integrin alpha-IIb; Integrin alpha-IIb; integrin alpha-IIb; GP IIb; alpha IIb; GPalpha IIb; platelet membrane glycoprotein IIb; platelet glycoprotein IIb of IIb/II Ia complex; integrin alpha 2b; GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD_antigen: CD41Cleaved into the following 2 chains:Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain

products gene name :

Itga2b/CD41

other gene names :

Itga2b; Itga2b; CD41; CD41B; GpIIb; AI172977; alphaIIb; GPIIb

uniprot entry name :

ITA2B_MOUSE

reactivity :

Mouse

sequence length :

1033

specificity :

This assay has high sensitivity and excellent specificity for detection of Mouse Itga2b/CD41. No significant cross-reactivity or interference between Mouse Itga2b/CD41 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates, cell culture supernates. Assay Type: Sandwich. Detection Range: 0.156 ng/ml-10 ng/ml. Sensitivity: 0.039 ng/ml

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul. Protein Biological Process 1: Cell Adhesion. Protein Biological Process 3: Cell adhesion

products description :

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for CD41 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any CD41 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for CD41 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of CD41 bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

159110663

ncbi acc num :

NP_034705.2

ncbi gb acc num :

NM_010575.2

uniprot acc num :

Q9QUM0

ncbi mol weight :

112,678 Da

ncbi pathways :

Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117303); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Dilated Cardiomyopathy Pathway (121495); Dilated Cardiomyopathy Pathway (121285); ECM-receptor Interaction Pathway (83265); ECM-receptor Interaction Pathway (479); Focal Adhesion Pathway (198353); Focal Adhesion Pathway (83264); Focal Adhesion Pathway (478); GRB2:SOS Provides Linkage To MAPK Signaling For Intergrins Pathway (575477)

uniprot summary :

ITGA2B: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Belongs to the integrin alpha chain family. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral. Cellular Component: cell surface; focal adhesion; membrane; integral to membrane; integrin complex; external side of plasma membrane. Molecular Function: identical protein binding; extracellular matrix binding; metal ion binding. Biological Process: integrin-mediated signaling pathway; cell-matrix adhesion; positive regulation of leukocyte migration; cell adhesion

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800