catalog number :
MBS9135428
products full name :
SUV420H1 Polyclonal Antibody
products short name :
[SUV420H1]
products name syn :
[CGI-85; CGI85; SUV420H1]
other names :
[histone-lysine N-methyltransferase KMT5B isoform 5; Histone-lysine N-methyltransferase KMT5B; histone-lysine N-methyltransferase KMT5B; lysine methyltransferase 5B; Lysine N-methyltransferase 5B; Lysine-specific methyltransferase 5B]
products gene name :
[SUV420H1]
other gene names :
[KMT5B; KMT5B; CGI85; MRD51; CGI-85; SUV420H1; Su(var)4-20 homolog 1; Suv4-20h1]
reactivity :
Human, Mouse, Rat
sequence :
MNTSAFPSRSSRHFSKSDSFSHNNPVRFRPIKGRQEELK
EVIERFKKDEHLEKAFKCLTSGEWARHYFLNKNKMQEKL
FKEHVFIYLRMFATDSGFEILPC
purity :
Affinity Purification
form :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
storage stability :
Store at -20 degree C. Avoid freeze / thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB: 1:200 - 1:2000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human SUV420H1 (NP_060105.3)
products categories :
Polyclonal Antibodies
products description :
This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
ncbi acc num :
NP_001287838.1
ncbi gb acc num :
NM_001300909.1
ncbi mol weight :
Calculated: 31kDa; 44kDa; 99kDa. Observed: 110kDa
ncbi pathways :
Glucocorticoid Receptor Regulatory Network Pathway (138014); Lysine Degradation Pathway (82956); Lysine Degradation Pathway (320)
ncbi summary :
This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
uniprot summary :
Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (). Plays a role in myogenesis by regulating the expression of target genes, such as EID3.