product summary
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company name :
MyBioSource
product type :
antibody
product name :
ALOX12 Polyclonal Antibody
catalog :
MBS9134695
quantity :
0.05 mL
price :
200 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
immunohistochemistry, immunocytochemistry
more info or order :
image
image 1 :
Immunohistochemistry of paraffin-embedded rat heart using ALOX12 antibody (MBS9134695) at dilution of 1:100 (40x lens)
image 2 :
Immunohistochemistry of paraffin-embedded human color carcinoma using ALOX12 antibody (MBS9134695) at dilution of 1:100 (40x lens).
image 3 :
Immunohistochemistry of paraffin-embedded mouse brain using ALOX12 antibody (MBS9134695) at dilution of 1:100 (40x lens).
product information
catalog number :
MBS9134695
products type :
Antibody
products full name :
ALOX12 Polyclonal Antibody
products short name :
[ALOX12]
products name syn :
[ALOX12;12-LOX;12SLOX;LOG12;arachidonate 12-lipoxygenase,12S-type]
other names :
[arachidonate 12-lipoxygenase, 12S-type; Arachidonate 12-lipoxygenase, 12S-type; arachidonate 12-lipoxygenase, 12S-type; arachidonate 12-lipoxygenase, 12S type; Lipoxin synthase 12-LO (EC:3.3.2.-); Platelet-type lipoxygenase 12]
products gene name :
[ALOX12]
other gene names :
[ALOX12; ALOX12; LOG12; 12-LOX; 12S-LOX; 12LO; LOG12; 12S-LOX; 12S-lipoxygenase]
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
663
purity :
Affinity purification
form :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
storage stability :
Store at -20°C Avoid freeze / thaw cycles.
tested application :
Immunohistochemistry (IHC), Immunoflorecence (IF)
app notes :
IHC: 1:50-1:200. IF: 1:50-1:200
image1 heading :
Immunohistochemistry(IHC)
image2 heading :
Immunohistochemistry (IHC)
image3 heading :
Immunohistochemistry (IHC)
image4 heading :
Immunohistochemistry (IHC)
image4 description :
Immunohistochemistry of paraffin-embedded mouse brain using ALOX12 antibody (MBS9134695) at dilution of 1:100 (40x lens).
image5 heading :
Immunofluorescence (IF)
image5 description :
Immunofluorescence analysis of rat lung using ALOX12 Polyclonal Antibody (MBS9134695) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
other info1 :
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 483-663 of human ALOX12 (NP_000688.2)
products categories :
Polyclonal Antibodies
ncbi gi num :
154426292
ncbi acc num :
NP_000688.2
ncbi gb acc num :
NM_000697.2
uniprot acc num :
P18054
ncbi mol weight :
75kDa
ncbi pathways :
Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (685553); Arachidonic Acid Metabolism Pathway (366); Eicosanoid Synthesis Pathway (198888); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Serotonergic Synapse Pathway (525336); Synthesis Of 12-eicosatetraenoic Acid Derivatives Pathway (730337); Synthesis Of Hepoxilins (HX) And Trioxilins (TrX) Pathway (730339); Synthesis Of Lipoxins (LX) Pathway (730338)
ncbi summary :
This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]
uniprot summary :
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.
size1 :
0.05 mL
price1 :
200 USD
size2 :
0.1 mL
price2 :
275
size3 :
0.2 mL
price3 :
430
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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