catalog number :
MBS9133741
products full name :
CELA3B Polyclonal Antibody
products short name :
[CELA3B]
products name syn :
[CBPP; ELA3B]
other names :
[chymotrypsin-like elastase family member 3B preproprotein; Chymotrypsin-like elastase family member 3B; chymotrypsin-like elastase family member 3B; chymotrypsin like elastase family member 3B; Elastase IIIB; Elastase-3B; Protease E]
products gene name :
[CELA3B]
other gene names :
[CELA3B; CELA3B; CBPP; ELA3B; ELA3B]
purity :
Affinity Purification
storage stability :
Store at -20°C. Avoid freeze / thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB: 1:500 - 1:2000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 80-190 of human CELA3B (NP_031378.1). Calculated: 29kDa. Observed: 29kDa
other info2 :
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
products categories :
Polyclonal Antibodies
products description :
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.
ncbi acc num :
NP_031378.1
ncbi gb acc num :
NM_007352.3
ncbi pathways :
Pancreatic Secretion Pathway (169306); Pancreatic Secretion Pathway (169295); Protein Digestion And Absorption Pathway (172847); Protein Digestion And Absorption Pathway (171868)
ncbi summary :
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]
uniprot summary :
Efficient protease with alanine specificity but only little elastolytic activity.