PTPN13 Polyclonal Antibody | MyBioSource MBS9133056 product information

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company name :

MyBioSource

product type :

antibody

product name :

PTPN13 Polyclonal Antibody

catalog :

MBS9133056

quantity :

0.05 mL

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts of various cell lines, using PTPN13 antibody (MBS9133056) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.

product information

catalog number :

MBS9133056

products type :

Antibody

products full name :

PTPN13 Polyclonal Antibody

products short name :

[PTPN13]

products name syn :

[PTPN13; FAP-1; PNP1; PTP-BAS; PTP-BL; PTP1E; PTPL1; PTPLE; hPTP1E; tyrosine-protein phosphotase non-receptor type 13]

other names :

[tyrosine-protein phosphatase non-receptor type 13 isoform 2; Tyrosine-protein phosphatase non-receptor type 13; tyrosine-protein phosphatase non-receptor type 13; protein tyrosine phosphatase, non-receptor type 13; Fas-associated protein-tyrosine phosphatase 1; FAP-1; PTP-BAS; Protein-tyrosine phosphatase 1E; PTP-E1; hPTPE1; Protein-tyrosine phosphatase PTPL1]

products gene name :

[PTPN13]

other gene names :

[PTPN13; PTPN13; PNP1; FAP-1; PTP1E; PTPL1; PTPLE; PTP-BL; hPTP1E; PTP-BAS; PNP1; PTP1E; PTPL1; FAP-1; PTP-E1; hPTPE1]

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

purity :

Affinity Purification

form :

PBS with 0.02% sodium azide, 50% glycerol, pH 7.3

storage stability :

Store at -20 degree C. Avoid freeze / thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

WB: 1:500 - 1:2000. IHC: 1:50 - 1:100. IF: 1:50 - 1:100

image1 heading :

Western Blot (WB)

other info1 :

Category: Polyclonal Antibodies. Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 250-500 of human PTPN13 (NP_542416.1).

products categories :

Polyclonal Antibodies

products description :

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.

ncbi gi num :

5453992

ncbi acc num :

NP_006255.1

ncbi gb acc num :

NM_006264.2

uniprot acc num :

Q12923

ncbi mol weight :

Calculated: 255kDa; 274kDa; 276kDa; 277kDa. Observed: 310kDa

ncbi pathways :

Apoptosis Modulation And Signaling Pathway (198822); Ephrin B Reverse Signaling Pathway (138052); Fc-epsilon Receptor I Signaling In Mast Cells Pathway (138050)

ncbi summary :

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]

uniprot summary :

Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317).

size1 :

0.05 mL

price1 :

200 USD

size2 :

0.1 mL

price2 :

275

size3 :

0.2 mL

price3 :

430

more info or order :

MyBioSource product webpage