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company name :
MyBioSource
product type :
antibody
product name :
Phospho-ULk1-S423 Polyclonal Antibody
catalog :
MBS9132871
quantity :
0.05 mL
price :
235 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot
more info or order :
product information
catalog number :
MBS9132871
products type :
Antibody
products full name :
Phospho-ULk1-S423 Polyclonal Antibody
products short name :
[ULk1-S423]
products name syn :
[ULK1; ATG1; ATG1A; UNC51; hATG1; Unc51.1; hATG1; serine/threonine-protein kinase ULK1]
other names :
[Serine/threonine-protein kinase ULK1; Serine/threonine-protein kinase ULK1; serine/threonine-protein kinase ULK1; unc-51 like autophagy activating kinase 1; Autophagy-related protein 1 homolog; ATG1; hATG1; Unc-51-like kinase 1]
products gene name :
[ULk1-S423]
other gene names :
[ULK1; ULK1; ATG1; ATG1A; UNC51; hATG1; Unc51.1; KIAA0722; ATG1; hATG1]
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
1050
purity :
Affinity Purification
form :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
storage stability :
Store at -20 degree C. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB: 1:500 - 1:2000
other info1 :
Immunogen: A phospho specific peptide corresponding to residues surrounding S423 of human ULk1
other info2 :
Category: Phosphorylated Antibodies
products categories :
Primary antibody
ncbi gi num :
317373288
ncbi acc num :
O75385.2
uniprot acc num :
O75385
ncbi mol weight :
Calculated: 112kDa
ncbi pathways :
AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Cellular Responses To Stress Pathway (1270414); Longevity Regulating Pathway (1319989); Macroautophagy Pathway (1270432); Regulation Of Autophagy Pathway (83058); Regulation Of Autophagy Pathway (468); Senescence And Autophagy Pathway (198780); TOR Signaling Pathway (198762); MTOR Signaling Pathway (83059)
uniprot summary :
ULK1: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. Interacts with GABARAP and GABARAPL2. Interacts (via C- terminus) with ATG13/KIAA0652. Part of a complex consisting of ATG13/KIAA0652, ULK1 and RB1CC1. Associates with the mammalian target of rapamycin complex 1 (mTORC1) through an interaction with RPTOR; the association depends on nutrient conditions and is reduced during starvation. Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Protein type: Autophagy; EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); ULK family. Chromosomal Location of Human Ortholog: 12q24.33. Cellular Component: autophagic vacuole; cytosol; endoplasmic reticulum membrane; pre-autophagosomal structure membrane; recycling endosome. Molecular Function: protein binding; protein complex binding; protein serine/threonine kinase activity; Rab GTPase binding. Biological Process: autophagy; axon extension; cellular response to nutrient levels; macroautophagy; negative regulation of protein complex assembly; neurite development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; protein amino acid autophosphorylation; protein localization; response to starvation
size1 :
0.05 mL
price1 :
235 USD
size2 :
0.1 mL
price2 :
350
size3 :
0.2 mL
price3 :
525
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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