Mouse Platelet glycoprotein Ib alpha chain, GP1BA ELISA Kit | MyBioSource MBS913168 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse Platelet glycoprotein Ib alpha chain, GP1BA ELISA Kit

catalog :

MBS913168

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS913168

products type :

ELISA Kit

products full name :

Mouse Platelet glycoprotein Ib alpha chain, GP1BA ELISA Kit

products short name :

glycoprotein Ib (platelet) , alpha polypeptide

products name syn :

Mouse Platelet glycoprotein Ib alpha chain (GP1BA) ELISA kit; BSS; CD42B; CD42b-alpha; GP1B; MGC34595; platelet glycoprotein Ib alpha polypeptide; platelet membrane glycoprotein 1b-alpha subunit; glycoprotein Ib (platelet); alpha polypeptide

other names :

platelet glycoprotein Ib alpha chain; Platelet glycoprotein Ib alpha chain; platelet glycoprotein Ib alpha chain; GP-Ib alpha; glycoprotein Ibalpha; glycoprotein 1b, alpha polypeptide; CD_antigen: CD42b

products gene name :

GP1BA

other gene names :

Gp1ba; Gp1ba; GPIba; GPIbalpha; GP-Ib alpha; GPIb-alpha; GPIbA; Glycoprotein Ibalpha

uniprot entry name :

GP1BA_MOUSE

reactivity :

Mouse

sequence length :

734

specificity :

This assay has high sensitivity and excellent specificity for detection of Mouse GP1BA. No significant cross-reactivity or interference between Mouse GP1BA and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates. Assay Type: Sandwich. Detection Range: 46.88 pg/ml-3000 pg/ml. Sensitivity: 11.72 pg/ml

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul. Protein Biological Process 1: Blood Coagulation. Protein Biological Process 3: Blood coagulation

products description :

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for GP1BA has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any GP1BA present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for GP1BA is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of GP1BA bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

158635962

ncbi acc num :

NP_034456.2

ncbi gb acc num :

NM_010326.2

uniprot acc num :

O35930

ncbi mol weight :

80,055 Da

ncbi pathways :

ECM-receptor Interaction Pathway (83265); ECM-receptor Interaction Pathway (479); Formation Of Fibrin Clot (Clotting Cascade) Pathway (575502); GP1b-IX-V Activation Signalling Pathway (575490); Hematopoietic Cell Lineage Pathway (83275); Hematopoietic Cell Lineage Pathway (489); Hemostasis Pathway (575479); Intrinsic Pathway (575504); Platelet Adhesion To Exposed Collagen Pathway (575488); Platelet Aggregation (Plug Formation) Pathway (575497)

uniprot summary :

GPIbA: GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium. Genetic variations in GP1BA may be a cause of susceptibility to non-arteritic anterior ischemic optic neuropathy (NAION). NAION is an ocular disease due to ischemic injury to the optic nerve. It usually affects the optic disk and leads to visual loss and optic disk swelling of a pallid nature. Visual loss is usually sudden, or over a few days at most and is usually permanent, with some recovery possibly occurring within the first weeks or months. Patients with small disks having smaller or non-existent cups have an anatomical predisposition for non-arteritic anterior ischemic optic neuropathy. As an ischemic episode evolves, the swelling compromises circulation, with a spiral of ischemia resulting in further neuronal damage. Defects in GP1BA are a cause of Bernard-Soulier syndrome (BSS); also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency. Defects in GP1BA are the cause of benign mediterranean macrothrombocytopenia (BMM); also known as autosomal dominant benign Bernard-Soulier syndrome. BMM is characterized by mild or no clinical symptoms, normal platelet function, and normal megakaryocyte count. Defects in GP1BA are the cause of pseudo-von Willebrand disease (VWDP). A bleeding disorder is caused by an increased affinity of GP-Ib for soluble vWF resulting in impaired hemostatic function due to the removal of vWF from the circulation. Protein type: Membrane protein, integral; Cell adhesion; Cell surface. Cellular Component: anchored to external side of plasma membrane; cell surface; membrane; integral to plasma membrane; plasma membrane; integral to membrane. Biological Process: fibrinolysis; hemostasis; cell morphogenesis; blood coagulation; cell adhesion

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage