product summary
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company name :
MyBioSource
product type :
antibody
product name :
ORAI1 Polyclonal Antibody
catalog :
MBS9131250
quantity :
0.1 mL
price :
275 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS9131250 image 1
Western blot analysis of extracts of various cell lines, using ORAI1 antibody (MBS9131250) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
product information
catalog number :
MBS9131250
products type :
Antibody
products full name :
ORAI1 Polyclonal Antibody
products short name :
[ORAI1]
products name syn :
[CRACM1; IMD9; ORAT1; TAM2; TMEM142A; ORAI calcium release activate calcium modulator 1]
other names :
[Calcium release-activated calcium channel protein 1; Calcium release-activated calcium channel protein 1; calcium release-activated calcium channel protein 1; ORAI calcium release-activated calcium modulator 1; Protein orai-1; Transmembrane protein 142A]
products gene name :
[ORAI1]
other gene names :
[ORAI1; ORAI1; IMD9; TAM2; ORAT1; CRACM1; TMEM142A; CRACM1; TMEM142A]
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse
sequence length :
301
purity :
Affinity Purification
storage stability :
Store at 4 degree C. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB: 1:500 - 1:1000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: A synthetic peptide of human ORAI1
other info2 :
Buffer: PBS with 0.02% sodium azide, pH7.3.
products categories :
Primary antibody
products description :
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1).
ncbi gi num :
97180269
ncbi acc num :
Q96D31.2
uniprot acc num :
Q96D31
ncbi mol weight :
Calculated MW: 25kDa/32kDa. Observed MW: 33kDa
ncbi pathways :
Adaptive Immune System Pathway (366160); Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway (576249); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Elevation Of Cytosolic Ca2+ Levels Pathway (106047); Hemostasis Pathway (106028); Immune System Pathway (106386); Platelet Activation Pathway (952858); Platelet Calcium Homeostasis Pathway (187202); Platelet Homeostasis Pathway (187198)
ncbi summary :
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]
uniprot summary :
ORAI1: Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. Interacts with STIM1 and STIM2. Interacts with EFCAB4B/CRACR2A; the interaction is direct and takes place in absence of Ca(2+). Forms a complex with EFCAB4B/CRACR2A and STIM1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Belongs to the Orai family. Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 12q24.31. Cellular Component: integral to plasma membrane; membrane. Molecular Function: identical protein binding; protein binding; store-operated calcium channel activity. Biological Process: positive regulation of calcium ion transport; regulation of calcium ion transport. Disease: Immunodeficiency 9; Myopathy, Tubular Aggregate, 2
size1 :
0.1 mL
price1 :
275 USD
size2 :
0.2 mL
price2 :
430
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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