catalog number :
MBS9131066
products full name :
PARG Polyclonal Antibody
products short name :
[PARG]
products name syn :
[PARG; PARG99; poly(ADP-ribose) glycohydrolase]
other names :
[Poly(ADP-ribose) glycohydrolase; Poly(ADP-ribose) glycohydrolase; poly(ADP-ribose) glycohydrolase; poly(ADP-ribose) glycohydrolase]
products gene name :
[PARG]
other gene names :
[PARG; PARG; PARG99]
reactivity :
Human, Mouse, Rat
purity :
Affinity Purification
storage stability :
Store at -20°C. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB: 1:1000 - 1:2000
other info1 :
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 777-976 of human PARG (NP_003622.2).
other info2 :
Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
products categories :
Primary antibody
products description :
Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. Several transcript variants encoding different isoforms have been found for this gene.
ncbi mol weight :
Calculated: 54kDa/60kDa/99kDa/102kDa/111kDa. Observed: 111kDa
ncbi pathways :
Biological Oxidations Pathway (1270189); Metabolism Pathway (1269956); Phase 1 - Functionalization Of Compounds Pathway (1270190)
ncbi summary :
Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
uniprot summary :
PARG: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Belongs to the poly(ADP-ribose) glycohydrolase family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.2.1.143; Hydrolase. Chromosomal Location of Human Ortholog: 10q11.23. Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; nucleoplasm; nucleus. Molecular Function: poly(ADP-ribose) glycohydrolase activity; protein binding