MMP16 Polyclonal Antibody | MyBioSource MBS9130916 product information

product summary

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company name :

MyBioSource

product type :

antibody

product name :

MMP16 Polyclonal Antibody

catalog :

MBS9130916

quantity :

0.05 mL

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts of various cell lines, using MMP16 antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.

image 2 :

Immunohistochemistry of paraffin-embedded human lung cancer using MMP16 antibody (MBS9130916) at dilution of 1:100 (40xlens)

image 3 :

Immunohistochemistry of paraffin-embedded human colon carcinoma using MMP16 antibody (MBS9130916) at dilution of 1:100 (40x lens).

product information

catalog number :

MBS9130916

products type :

Antibody

products full name :

MMP16 Polyclonal Antibody

products short name :

[MMP16]

products name syn :

[MMP16; C8orf57; MMP-X2; MT-MMP2; MT-MMP3; MT3- MMP; matrix metallopeptidase 16]

other names :

[Matrix metalloproteinase-16; Matrix metalloproteinase-16; matrix metalloproteinase-16; matrix metallopeptidase 16; MMP-X2; Membrane-type matrix metalloproteinase 3; MT-MMP 3; MTMMP3; Membrane-type-3 matrix metalloproteinase; MT3-MMP; MT3MMP]

products gene name :

[MMP16]

other gene names :

[MMP16; MMP16; MMP-X2; C8orf57; MT-MMP2; MT-MMP3; MT3-MMP; MMPX2; MMP-16; MT-MMP 3; MTMMP3; MT3-MMP; MT3MMP]

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

607

purity :

Affinity Purification

storage stability :

Store at -20°C. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

WB: 1:500 - 1:2000. IHC 1:50-1:200. IF 1:50-1:200

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

image4 heading :

Immunohistochemistry (IHC)

image4 description :

Immunohistochemistry of paraffin-embedded human breast using MMP16 antibody (MBS9130916) at dilution of 1:100 (40x lens).

image5 heading :

Immunohistochemistry (IHC)

image5 description :

Immunohistochemistry of paraffin-embedded human breast cancer using MMP16 antibody (MBS9130916) at dilution of 1:100 (40x lens)

other info1 :

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 290-565 of human MMP16 (NP_005932.2).

other info2 :

Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

products categories :

Primary antibody

products description :

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16.

ncbi gi num :

3041669

ncbi acc num :

P51512.2

uniprot acc num :

P51512

ncbi mol weight :

Observed MW: 60kDa. Calculated MW: 52kDa/69kDa

ncbi pathways :

Activation Of Matrix Metalloproteinases Pathway (576264); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262); Matrix Metalloproteinases Pathway (198900); MicroRNAs In Cancer Pathway (852705); MicroRNAs In Cancer Pathway (852928)

ncbi summary :

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]

uniprot summary :

MMP16: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. Belongs to the peptidase M10A family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.4.24.-; Membrane protein, integral; Protease. Chromosomal Location of Human Ortholog: 8q21.3. Cellular Component: Golgi lumen; integral to plasma membrane; plasma membrane. Molecular Function: enzyme activator activity; metalloendopeptidase activity; zinc ion binding. Biological Process: extracellular matrix disassembly; protein metabolic process; protein processing; proteolysis

size1 :

0.05 mL

price1 :

200 USD

size2 :

0.1 mL

price2 :

275

size3 :

0.2 mL

price3 :

430

more info or order :

MyBioSource product webpage