product summary
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company name :
MyBioSource
product type :
antibody
product name :
GIPR Polyclonal Antibody
catalog :
MBS9130625
quantity :
0.05 mL
price :
200 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot
more info or order :
image
image 1 :
Western blot analysis of extracts of various cell lines, using GIPR antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
product information
catalog number :
MBS9130625
products type :
Antibody
products full name :
GIPR Polyclonal Antibody
products short name :
[GIPR]
products name syn :
[GIPR; PGQTL2; gastric inhibitory polypeptide receptor]
other names :
[gastric inhibitory polypeptide receptor isoform 1; Gastric inhibitory polypeptide receptor; gastric inhibitory polypeptide receptor; gastric inhibitory polypeptide receptor; Glucose-dependent insulinotropic polypeptide receptor]
products gene name :
[GIPR]
other gene names :
[GIPR; GIPR; PGQTL2; GIP-R]
uniprot entry name :
GIPR_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
466
purity :
Affinity purification
storage stability :
Store at -20 degree C. Avoid freeze / thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB: 1:500 - 1:2000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 22-138 of human GIPR (NP_000155.1).
other info2 :
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
products categories :
Polyclonal
products description :
This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.
ncbi gi num :
4503999
ncbi acc num :
NP_000155.1
ncbi gb acc num :
NM_000164.3
uniprot acc num :
P48546
ncbi mol weight :
Observed MW: 45kDa. Calculated MW: 48kDa/49kDa/53kDa
ncbi pathways :
Class B/2 (Secretin Family Receptors) Pathway (1269570); G Alpha (s) Signalling Events Pathway (1269575); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); GPCRs, Class B Secretin-like Pathway (198781); Glucagon-type Ligand Receptors Pathway (1269572); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Signal Transduction Pathway (1269379); Signaling By GPCR Pathway (1269543)
ncbi summary :
This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]
uniprot summary :
GIPR: This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 2. Chromosomal Location of Human Ortholog: 19q13.3. Cellular Component: cytosol; integral to membrane; plasma membrane. Molecular Function: gastric inhibitory peptide receptor activity; peptide hormone binding; transmembrane receptor activity. Biological Process: adenylate cyclase activation; cell surface receptor linked signal transduction; desensitization of G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; endocrine pancreas development; generation of precursor metabolites and energy; positive regulation of insulin secretion; response to axon injury; response to calcium ion; response to glucose stimulus; response to nutrient
size1 :
0.05 mL
price1 :
200 USD
size2 :
0.1 mL
price2 :
275
size3 :
0.2 mL
price3 :
430
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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