antibody

DUOX1 Polyclonal Antibody

MBS9130502

0.05 mL

200 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

Antibody

DUOX1 Polyclonal Antibody

[DUOX1]

[LNOX1; THOX1; NOXEF1]

[dual oxidase 1; Dual oxidase 1; dual oxidase 1; dual oxidase 1; Large NOX 1; Long NOX 1; NADPH thyroid oxidase 1; Thyroid oxidase 1]

[DUOX1]

[DUOX1; DUOX1; LNOX1; THOX1; NOXEF1; DUOX; LNOX1; THOX1]

DUOX1_HUMAN

Polyclonal

IgG

Rabbit

Mouse, Rat

Affinity purification

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20°C. Avoid freeze / thaw cycles.

Western Blot (WB)

WB: 1:500 - 1:2000

Western Blot (WB)

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1312-1551 of human DUOX1 (NP_059130.2)

Polyclonal

The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.

20149640

NP_059130.2

NM_017434.4

Q9NRD9

Calculated: 37kDa/177kDa; Observed: 80 kDa

Amine-derived Hormones Pathway (1270175); Metabolism Pathway (1269956); Metabolism Of Amino Acids And Derivatives Pathway (1270158); Thyroxine Biosynthesis Pathway (1270177)

The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]

DUOX1: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Membrane protein, integral; EC 1.6.3.1; Oxidoreductase. Chromosomal Location of Human Ortholog: 15q15.3. Cellular Component: apical plasma membrane; integral to membrane; plasma membrane. Molecular Function: calcium ion binding; heme binding; NAD(P)H oxidase activity; NADP binding; peroxidase activity. Biological Process: cuticle development; cytokine and chemokine mediated signaling pathway; hormone biosynthetic process; hydrogen peroxide biosynthetic process; hydrogen peroxide catabolic process; response to cAMP; response to oxidative stress; superoxide release; thyroid hormone generation

0.05 mL

200 USD

0.1 mL

275

0.2 mL

430