catalog number :
MBS9130387
products full name :
C5AR1 Polyclonal Antibody
products short name :
[C5AR1]
products name syn :
[C5A;C5AR;C5R1;CD88]
other names :
[C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin chemotactic receptor 1; complement component 5a receptor 1; C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR; CD_antigen: CD88]
products gene name :
[C5AR1]
other gene names :
[C5AR1; C5AR1; C5A; C5AR; C5R1; CD88; C5AR; C5R1; C5a-R; C5aR]
uniprot entry name :
C5AR1_HUMAN
purity :
Affinity purification
storage stability :
Store at -20°C. Avoid freeze / thaw cycles.
tested application :
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
app notes :
WB: 1:500 - 1:2000
other info1 :
Source: Rabbit. Immunogen: Recombinant funsion protein containing a sequence corresponding to amino acids 250-350 of human C5AR1
(NP_001727.1). Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
other info2 :
Calculated mw: 39kDa
products categories :
Polyclonal
ncbi acc num :
NP_001727.1
ncbi gb acc num :
NM_001736.3
ncbi mol weight :
Calculated MW: 39kDa. Molecular Weight: 350
ncbi pathways :
Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); G Alpha (i) Signalling Events Pathway (1269576); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Peptide GPCRs Pathway (198897)
uniprot summary :
C5aR: a family 1 G-protein coupled receptor that stimulates the GTPase activity of Gi2. Receptor for the chemotactic and inflammatory complement factor C5a. Stimulates chemotaxis, granule enzyme release and superoxide anion production. Phosphorylated in response to C5a or after stimulation of cells with phorbol esters. Expressed on monocytes, granulocytes, dendritic cells, astrocytes and microglia. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1. Chromosomal Location of Human Ortholog: 19q13.3-q13.4. Cellular Component: apical part of cell; basolateral plasma membrane; cell surface; cytoplasmic membrane-bound vesicle; cytosol; integral to plasma membrane; plasma membrane. Molecular Function: C5a anaphylatoxin receptor activity; complement component C5a binding; complement component C5a receptor activity. Biological Process: activation of MAPK activity; apoptosis; cell proliferation in hindbrain; cellular defense response; chemotaxis; defense response to Gram-positive bacterium; elevation of cytosolic calcium ion concentration; immune response; inflammatory response; mRNA transcription from RNA polymerase II promoter; negative regulation of neuron apoptosis; neutrophil chemotaxis; organ regeneration; phospholipase C activation; positive regulation of angiogenesis; positive regulation of epithelial cell proliferation; response to lipopolysaccharide; response to peptidoglycan; sensory perception of chemical stimulus; signal transduction