product summary
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company name :
MyBioSource
product type :
antibody
product name :
INSIG2 Polyclonal Antibody
catalog :
MBS9129599
quantity :
0.05 mL
price :
200 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot
more info or order :
image
image 1 :
Western blot analysis of extracts of various cell lines, using INSIG2 antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 1.
product information
catalog number :
MBS9129599
products type :
Antibody
products full name :
INSIG2 Polyclonal Antibody
products short name :
[INSIG2]
other names :
[insulin-induced gene 2 protein isoform a; Insulin-induced gene 2 protein; insulin-induced gene 2 protein; insulin induced gene 2]
products gene name :
[INSIG2]
other gene names :
[INSIG2; INSIG2; INSIG-2; INSIG-2]
uniprot entry name :
INSI2_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse
sequence length :
225
purity :
Affinity purification
storage stability :
Store at -20°C. Avoid freeze / thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB: 1:500 - 1:2000,
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human INSIG2 (NP_057217.2). Calculated MW: 24kDa. Observed MW: 27kDa
other info2 :
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
products categories :
Polyclonal
products description :
The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.
ncbi gi num :
38327533
ncbi acc num :
NP_057217.2
ncbi gb acc num :
NM_016133.3
uniprot acc num :
Q9Y5U4
ncbi pathways :
Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); Regulation Of Cholesterol Biosynthesis By SREBP (SREBF) Pathway (1270038); SREBP Signalling Pathway (219802)
ncbi summary :
The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]
uniprot summary :
INSIG2: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR. Belongs to the INSIG family. Protein type: Membrane protein, multi-pass; Endoplasmic reticulum; Membrane protein, integral; Transcription, coactivator/corepressor. Chromosomal Location of Human Ortholog: 2q14.2. Cellular Component: endoplasmic reticulum membrane. Molecular Function: protein binding; transcription factor binding. Biological Process: cholesterol biosynthetic process; inner ear morphogenesis; middle ear morphogenesis; negative regulation of fatty acid biosynthetic process; palate development; response to insulin stimulus; SREBP-mediated signaling pathway; triacylglycerol metabolic process
size1 :
0.05 mL
price1 :
200 USD
size2 :
0.1 mL
price2 :
275
size3 :
0.2 mL
price3 :
430
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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