antibody

ZC3HAV1 Polyclonal Antibody

MBS9129507

0.05 mL

200 USD

polyclonal

rabbit

nonconjugated

human, mouse

Antibody

ZC3HAV1 Polyclonal Antibody

[ZC3HAV1]

[ZC3HAV1; ARTD13; FLB6421; PARP13; ZAP; ZC3H2; ZC3HDC2; zinc finger CCCH-type antiviral protein 1]

[zinc finger CCCH-type antiviral protein 1 isoform 1; Zinc finger CCCH-type antiviral protein 1; zinc finger CCCH-type antiviral protein 1; zinc finger CCCH-type containing, antiviral 1; ADP-ribosyltransferase diphtheria toxin-like 13; ARTD13; Zinc finger CCCH domain-containing protein 2; Zinc finger antiviral protein; ZAP]

[ZC3HAV1]

[ZC3HAV1; ZC3HAV1; ZAP; ZC3H2; ARTD13; PARP13; FLB6421; ZC3HDC2; ZC3HDC2; ARTD13; ZAP]

ZCCHV_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse

Affinity purification

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20 degree C. Avoid freeze / thaw cycles.

Western Blot (WB)

WB: 1:500 - 1:2000

Western Blot (WB)

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 150-400 of human ZC3HAV1 (NP_078901.3).

Polyclonal

This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described.

27477136

NP_064504.2

NM_020119.3

Q7Z2W4

Observed: 101kDa. Calculated: 18kDa/42kDa/67kDa/77kDa/101kDa

This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described. [provided by RefSeq, Jul 2008]

ZAP: Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)- specific ribonuclease PARN to remove the poly(A) tail, and the 3'- 5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). 5 isoforms of the human protein are produced by alternative splicing. Protein type: Transferase; RNA-binding. Chromosomal Location of Human Ortholog: 7q34. Cellular Component: cytoplasm; Golgi apparatus; late endosome; lysosome; nucleus. Molecular Function: metal ion binding; NAD+ ADP-ribosyltransferase activity; protein binding. Biological Process: defense response to virus; innate immune response; metabolic process; negative regulation of viral genome replication; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon type I production; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; regulation of defense response to virus by host; response to virus

0.05 mL

200 USD

0.1 mL

275

0.2 mL

430