catalog number :
MBS9129501
products full name :
ROBO2 Polyclonal Antibody
products short name :
[ROBO2]
products name syn :
[SAX3]
other names :
[roundabout homolog 2 isoform ROBO2a; Roundabout homolog 2; roundabout homolog 2; roundabout guidance receptor 2]
products gene name :
[ROBO2]
other gene names :
[ROBO2; ROBO2; SAX3; KIAA1568]
uniprot entry name :
ROBO2_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Affinity purification
storage stability :
Store at -20 degree C. Avoid freeze / thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB: 1:500 - 1:2000
image1 heading :
Western Blot (WB)
other info1 :
Source: Rabbit. Immunogen: Recombinant protein of human ROBO2
other info2 :
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
products categories :
Polyclonal
products description :
The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants.
ncbi acc num :
NP_001122401.1
ncbi gb acc num :
NM_001128929.3
ncbi pathways :
Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (1270303); Developmental Biology Pathway (1270302); Regulation Of Commissural Axon Pathfinding By Slit And Robo Pathway (1270319); Signaling By Robo Receptor Pathway (1270318)
ncbi summary :
The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
uniprot summary :
Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.