product summary
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company name :
MyBioSource
product type :
antibody
product name :
SLC22A2 Polyclonal Antibody
catalog :
MBS9128659
quantity :
0.05 mL
price :
200 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, rat
application :
western blot
more info or order :
image
image 1 :
Western blot analysis of extracts of rat brain, using SLC22A2 antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
product information
catalog number :
MBS9128659
products type :
Antibody
products full name :
SLC22A2 Polyclonal Antibody
products short name :
[SLC22A2]
products name syn :
[OCT2;]
other names :
[solute carrier family 22 member 2; Solute carrier family 22 member 2; solute carrier family 22 member 2; solute carrier family 22 (organic cation transporter), member 2; Organic cation transporter 2; hOCT2]
products gene name :
[SLC22A2]
other gene names :
[SLC22A2; SLC22A2; OCT2; OCT2; hOCT2]
uniprot entry name :
S22A2_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Rat
sequence length :
242
purity :
Affinity Purification
storage stability :
Store at -20 degree C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
tested application :
Western Blot (WB)
app notes :
WB 1:500 - 1:2000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Recombinant protein of human SLC22A2. Category Primary: antibody
products description :
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.
ncbi gi num :
302148518
ncbi acc num :
NP_003049.2
ncbi gb acc num :
NM_003058.3
uniprot acc num :
O15244
ncbi mol weight :
Observed MW: 80kDa. Calculated MW: 26kDa/54kDa/62kDa
ncbi pathways :
Abacavir Transmembrane Transport Pathway (1270227); Abacavir Transport And Metabolism Pathway (1270226); Choline Metabolism In Cancer Pathway (1059539); Choline Metabolism In Cancer Pathway (1084232); Metabolism Pathway (1269956); Na+/Cl- Dependent Neurotransmitter Transporters Pathway (1269934); Neuronal System Pathway (1268763); Neurotransmitter Clearance In The Synaptic Cleft Pathway (1268778); Neurotransmitter Release Cycle Pathway (1268768); Norepinephrine Neurotransmitter Release Cycle Pathway (1268769)
ncbi summary :
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]
uniprot summary :
SLC22A2: Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Transporter; Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral. Chromosomal Location of Human Ortholog: 6q25.3. Cellular Component: membrane; integral to plasma membrane; basolateral plasma membrane; plasma membrane. Molecular Function: organic cation transmembrane transporter activity; quaternary ammonium group transmembrane transporter activity; steroid binding; choline transmembrane transporter activity. Biological Process: histamine transport; synaptic transmission; quaternary ammonium group transport; organic cation transport; neurotransmitter secretion; multidrug transport; choline transport; body fluid secretion; transmembrane transport; neurotransmitter biosynthetic process
size1 :
0.05 mL
price1 :
200 USD
size2 :
0.1 mL
price2 :
275
size3 :
0.2 mL
price3 :
430
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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