catalog number :
MBS9128199
products full name :
NPTN Polyclonal Antibody
products short name :
[NPTN]
products name syn :
[NPTN; GP55; GP65; SDFR1; SDFR1; SDR1; np55; np65; neuroplastin.]
other names :
[neuroplastin isoform c; Neuroplastin; neuroplastin; neuroplastin; Stromal cell-derived receptor 1; SDR-1]
products gene name :
[NPTN]
other gene names :
[NPTN; NPTN; GP55; GP65; SDR1; np55; np65; SDFR1; SDFR1; SDR1; SDR-1]
uniprot entry name :
NPTN_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Affinity Purification
storage stability :
Store at -20°C. Avoid freeze / thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB 1:500 - 1:2000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 29-200 of human NPTN (NP_059429.1). Calculated MW: 30kDa/ 31kDa/ 37 kDa/ 43 kDa/ 44 kDa. Observed MW: 45 kDa. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
products description :
This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants.
ncbi acc num :
NP_001154835.1
ncbi gb acc num :
NM_001161363.1
ncbi summary :
This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2009]
uniprot summary :
neuroplastin: Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Cell development/differentiation. Chromosomal Location of Human Ortholog: 15q22. Cellular Component: presynaptic membrane; cell surface; integral to membrane. Molecular Function: cell adhesion molecule binding; transmembrane receptor protein tyrosine kinase activity; ATP binding; type 1 fibroblast growth factor receptor binding. Biological Process: elevation of cytosolic calcium ion concentration; peptidyl-tyrosine phosphorylation; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of protein amino acid phosphorylation; homophilic cell adhesion; positive regulation of long-term neuronal synaptic plasticity; transmembrane receptor protein tyrosine kinase signaling pathway