Human Fibroblast growth factor 18, FGF18 ELISA Kit | MyBioSource MBS912811 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Fibroblast growth factor 18, FGF18 ELISA Kit

catalog :

MBS912811

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS912811

products type :

ELISA Kit

products full name :

Human Fibroblast growth factor 18, FGF18 ELISA Kit

products short name :

fibroblast growth factor 18

products name syn :

Human Fibroblast growth factor 18 (FGF18) ELISA kit; FGF-18; ZFGF5; ; fibroblast growth factor 18

other names :

fibroblast growth factor 18; Fibroblast growth factor 18; fibroblast growth factor 18; fibroblast growth factor 18; zFGF5

products gene name :

FGF18

other gene names :

FGF18; FGF18; ZFGF5; FGF-18; UNQ420/PRO856; FGF-18

uniprot entry name :

FGF18_HUMAN

reactivity :

Human

sequence length :

207

specificity :

This assay has high sensitivity and excellent specificity for detection of human FGF18. No significant cross-reactivity or interference between human FGF18 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, cell culture supernates and tissue homogenates. Assay Type: Sandwich. Detection Range: 31.25 pg/ml-2000 pg/ml. Sensitivity: Typically less than 7.81 pg/ml

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

products description :

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for FGF18 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any FGF18 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for FGF18 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of FGF18 bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

4503695

ncbi acc num :

NP_003853.1

ncbi gb acc num :

NM_003862.2

uniprot acc num :

O76093

ncbi mol weight :

23,989 Da

ncbi pathways :

Downstream Signaling Of Activated FGFR Pathway (160957); Endochondral Ossification Pathway (198812); FGFR Ligand Binding And Activation Pathway (106344); FGFR2 Ligand Binding And Activation Pathway (106349); FGFR2c Ligand Binding And Activation Pathway (106351); FGFR3 Ligand Binding And Activation Pathway (106352); FGFR3b Ligand Binding And Activation Pathway (106353); FGFR3c Ligand Binding And Activation Pathway (106354); FGFR4 Ligand Binding And Activation Pathway (106355); FRS2-mediated Cascade Pathway (160958)

ncbi summary :

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]

uniprot summary :

FGF18: Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation. Belongs to the heparin-binding growth factors family. Protein type: Secreted, signal peptide; Cytokine; Secreted. Chromosomal Location of Human Ortholog: 5q34. Cellular Component: extracellular space; nucleolus; extracellular region. Molecular Function: growth factor activity; type 2 fibroblast growth factor receptor binding; type 1 fibroblast growth factor receptor binding. Biological Process: epidermal growth factor receptor signaling pathway; nervous system development; intramembranous ossification; anatomical structure morphogenesis; regulation of endothelial cell proliferation; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; chondrocyte development; signal transduction; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of MAP kinase activity; positive regulation of chondrocyte differentiation; cell-cell signaling; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response; angiogenesis; endochondral ossification; lung development

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage