ABHD5 Polyclonal Antibody | MyBioSource MBS9127454 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ABHD5 Polyclonal Antibody

catalog :

MBS9127454

quantity :

0.05 mL

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts of Jurkat cells, using ABHD5 antibody. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.

product information

catalog number :

MBS9127454

products type :

Antibody

products full name :

ABHD5 Polyclonal Antibody

products short name :

[ABHD5]

products name syn :

[CDS; CGI58; IECN2; NCIE2]

other names :

[1-acylglycerol-3-phosphate O-acyltransferase ABHD5; 1-acylglycerol-3-phosphate O-acyltransferase ABHD5; 1-acylglycerol-3-phosphate O-acyltransferase ABHD5; lipid droplet-binding protein CGI-58; abhydrolase domain-containing protein 5; abhydrolase domain containing 5; Abhydrolase domain-containing protein 5; Lipid droplet-binding protein CGI-58]

products gene name :

[ABHD5]

other gene names :

[ABHD5; ABHD5; CDS; CGI58; IECN2; NCIE2; NCIE2]

uniprot entry name :

ABHD5_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

349

purity :

Affinity Purification

storage stability :

Store at -20°C. Avoid freeze / thaw cycles.

tested application :

Western Blot (WB)

app notes :

WB: 1:200 - 1:2000

image1 heading :

Western Blot (WB)

other info1 :

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

other info2 :

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-349 of human ABHD5 (NP_057090.2) . Calculated MW: 39 kDa. Observed MW: 39 kDa

products categories :

Polyclonal

products description :

The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation.

ncbi gi num :

73921640

ncbi acc num :

Q8WTS1.1

uniprot acc num :

Q8WTS1

ncbi pathways :

CDP-diacylglycerol Biosynthesis Pathway (142255); Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway (106121); Lipid Digestion, Mobilization, And Transport Pathway (106111); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Triacylglycerol Biosynthesis Pathway (142242)

ncbi summary :

uniprot summary :

ABHD5: a lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Colocalized with PLIN and ADFP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA. Defects cause neutral lipid storage disease (NLSD), an autosomal recessive disorder characterized by the excessive accumulation of neutral lipids in multiple tissues, and Chanarin-Dorfman syndrome (CDS), a triglyceride storage disease with impaired long-chain fatty acid oxidation and icthyosis. CDS is an autosomal recessive inborn error of lipid metabolism with multisystemic accumulation of triglycerides although plasma concentrations are normal. Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons. Protein type: Transferase; EC 2.3.1.51; Lipase. Chromosomal Location of Human Ortholog: 3p21. Cellular Component: intracellular membrane-bound organelle; cytoplasm; lipid particle; nucleus; cytosol. Molecular Function: triacylglycerol lipase activity; 1-acylglycerol-3-phosphate O-acyltransferase activity; lysophosphatidic acid acyltransferase activity. Biological Process: triacylglycerol catabolic process; phosphatidic acid biosynthetic process; positive regulation of lipoprotein lipase activity; fatty acid metabolic process; cell differentiation. Disease: Chanarin-dorfman Syndrome

size1 :

0.05 mL

price1 :

200 USD

size2 :

0.1 mL

price2 :

275

size3 :

0.2 mL

price3 :

430

more info or order :

MyBioSource product webpage